| Accession | ARO:0000062 |
| Synonym(s) | Ceftriazone Ceftriaxonum Longaceph Rocephin Cefatriaxone Ceftriaxona Ceftriaxon Biotrakson Longacef CRO |
| Definition | Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. |
| Drug Class | cephalosporin |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + cephalosporin [Drug Class] |
| Sub-Term(s) | 28 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + Neisseria meningititis PBP2 conferring resistance to beta-lactam confers_resistance_to_antibiotic + Acinetobacter baumannii AbuO confers_resistance_to_antibiotic + MexAB-OprM confers_resistance_to_antibiotic + MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic + Serratia marcescens Omp1 confers_resistance_to_antibiotic + SHV-12 confers_resistance_to_antibiotic + CTX-M-55 confers_resistance_to_antibiotic + CTX-M-3 confers_resistance_to_antibiotic + Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic + MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic + MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic + MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic + Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam confers_resistance_to_antibiotic + CTX-M-15 confers_resistance_to_antibiotic + Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + blaS1 confers_resistance_to_antibiotic + CMY-2 confers_resistance_to_antibiotic + PDC-3 confers_resistance_to_antibiotic + PDC-5 confers_resistance_to_antibiotic + VAM-1 confers_resistance_to_antibiotic + PRC-1 confers_resistance_to_antibiotic + Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic + Klebsiella pneumoniae OmpK36 confers_resistance_to_antibiotic + VMB-1 confers_resistance_to_antibiotic + CAE-1 confers_resistance_to_antibiotic + IreK confers_resistance_to_antibiotic |
| Publications | Neu HC. 1982. Ann Intern Med 97(3): 408-419. The new beta-lactamase-stable cephalosporins. (PMID 6810737) |
