| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:0000062 |
| Synonym(s) | Biotrakson Cefatriaxone Ceftriaxon Ceftriaxona Ceftriaxonum Ceftriazone CRO Longacef Longaceph Rocephin |
| Definition | Ceftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. |
| SMILES | CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(O)nn3C)CS[C@H]12)c1csc(N)n1 |
| PubChem | 5479530 |
| ChEMBL | CHEMBL161 |
| ChEBI | 29007 |
| CAS | 73384-59-5 |
| Drug Class | cephalosporin |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 24 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + Neisseria meningititis PBP2 conferring resistance to beta-lactam confers_resistance_to_antibiotic + Acinetobacter baumannii AbuO confers_resistance_to_antibiotic + MexAB-OprM confers_resistance_to_antibiotic + Serratia marcescens Omp1 confers_resistance_to_antibiotic + SHV-12 confers_resistance_to_antibiotic + CTX-M-55 confers_resistance_to_antibiotic + CTX-M-3 confers_resistance_to_antibiotic + Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic + Neisseria gonorrhoeae pilQ gene conferring resistance to beta-lactam confers_resistance_to_antibiotic + CTX-M-15 confers_resistance_to_antibiotic + Neisseria gonorrhoeae PBP2 conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + blaS1 confers_resistance_to_antibiotic + CMY-2 confers_resistance_to_antibiotic + PDC-3 confers_resistance_to_antibiotic + PDC-5 confers_resistance_to_antibiotic + VAM-1 confers_resistance_to_antibiotic + PRC-1 confers_resistance_to_antibiotic + Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic + Klebsiella pneumoniae OmpK36 confers_resistance_to_antibiotic + VMB-1 confers_resistance_to_antibiotic + CAE-1 confers_resistance_to_antibiotic + IreK confers_resistance_to_antibiotic |
| Publications | Neu HC. 1982. Ann Intern Med 97(3): 408-419. The new beta-lactamase-stable cephalosporins. (PMID 6810737) |
| Curator | Description | Most Recent Edit |
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