ceftriaxone [Antibiotic]

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Accession ARO:0000062
Synonym(s)Ceftriazone Ceftriaxonum Longaceph Rocephin Cefatriaxone Ceftriaxona Ceftriaxon Biotrakson Longacef CRO
DefinitionCeftriaxone is a third-generation cephalosporin antibiotic. The presence of an aminothiazolyl sidechain increases ceftriazone's resistance to beta-lactamases. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria.
Drug Classcephalosporin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephalosporin [Drug Class]
Sub-Term(s)
14 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ Neisseria meningititis PBP2 conferring resistance to beta-lactam confers_resistance_to_antibiotic
+ Acinetobacter baumannii AbuO confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ Serratia marcescens Omp1 confers_resistance_to_antibiotic
+ SHV-12 confers_resistance_to_antibiotic
+ CTX-M-55 confers_resistance_to_antibiotic
+ CTX-M-3 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic
+ MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic
+ MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic
+ CTX-M-15
Publications

Neu HC. 1982. Ann Intern Med 97(3): 408-419. The new beta-lactamase-stable cephalosporins. (PMID 6810737)