| Accession | ARO:3001878 |
| Synonym(s) | UOE-1 |
| CARD Short Name | CTX-M-15 |
| Definition | CTX-M-15 is a beta-lactamase found in the Enterobacteriaceae family. |
| AMR Gene Family | CTX-M beta-lactamase |
| Drug Class | penam, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+wgs, Citrobacter freundiip+wgs, Citrobacter koseriwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Escherichia marmotaewgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Morganella morganiig+wgs, Proteus mirabilisg+wgs, Providencia rettgeriwgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+wgs, Raoultella planticolawgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella boydiiwgs, Shigella dysenteriaewgs, Shigella flexnerig+p+wgs, Shigella sonneig+p+wgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs, Citrobacter freundiip+wgs, Citrobacter koseriwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Escherichia marmotaewgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Morganella morganiig+wgs, Proteus mirabilisg+wgs, Providencia rettgeriwgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+wgs, Raoultella planticolawgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella boydiiwgs, Shigella dysenteriaewgs, Shigella flexnerig+p+wgs, Shigella sonneig+p+wgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + determinant of antibiotic resistance + beta-lactam antibiotic + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + penam [Drug Class] + cephalosporin [Drug Class] + class A beta-lactamase |
| Parent Term(s) | 6 ontology terms | Show + CTX-M beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] + confers_resistance_to_antibiotic cefalotin [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + confers_resistance_to_antibiotic cefazolin [Antibiotic] |
| Sub-Term(s) | 12 ontology terms | Show + tazobactam [Adjuvant] is_small_molecule_inhibitor + clavulanic acid [Adjuvant] is_small_molecule_inhibitor + sulbactam [Adjuvant] is_small_molecule_inhibitor + ANT3310 [Adjuvant] is_small_molecule_inhibitor + avibactam [Adjuvant] is_small_molecule_inhibitor + vaborbactam [Adjuvant] is_small_molecule_inhibitor + Xeruborbactam [Adjuvant] is_small_molecule_inhibitor + taniborbactam [Adjuvant] is_small_molecule_inhibitor + nacubactam [Adjuvant] is_small_molecule_inhibitor + ARX1796 [Adjuvant] is_small_molecule_inhibitor + ledaborbactam [Adjuvant] is_small_molecule_inhibitor + ledaborbactam etzadroxil [Adjuvant] is_small_molecule_inhibitor |
| Publications | Karim A, et al. 2001. FEMS Microbiol Lett 201(2): 237-241. Plasmid-mediated extended-spectrum beta-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1. (PMID 11470367) Poirel L, et al. 2002. J. Antimicrob. Chemother. 50(6):1031-4 Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum beta-lactamase CTX-M-15 and of its structurally related beta-lactamase CTX-M-3. (PMID 12461028) Tsang KK, et al. 2021. Microb Genom 7(1): Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance. (PMID 33416461) |
Prevalence of CTX-M-15 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.35% | 0% | 0.16% | 0% |
| Citrobacter freundii | 0% | 0.62% | 6.96% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Citrobacter portucalensis | 0% | 0% | 3.6% | 0% |
| Citrobacter werkmanii | 0% | 0% | 17.95% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Enterobacter asburiae | 0% | 0.28% | 1.98% | 0% |
| Enterobacter chengduensis | 0% | 0% | 12% | 0% |
| Enterobacter cloacae | 1.79% | 0.56% | 9.9% | 0% |
| Enterobacter hormaechei | 0.72% | 1.03% | 8.55% | 0% |
| Enterobacter kobei | 0% | 0% | 2.62% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.36% | 0% |
| Escherichia coli | 2.55% | 1.48% | 5.66% | 0% |
| Escherichia marmotae | 0% | 0% | 4.17% | 0% |
| Klebsiella aerogenes | 0% | 1.09% | 2.26% | 0% |
| Klebsiella michiganensis | 6.45% | 2.29% | 3.19% | 0% |
| Klebsiella oxytoca | 0% | 4.11% | 2.1% | 0% |
| Klebsiella pneumoniae | 10.83% | 5.41% | 20.83% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.48% | 15.92% | 0% |
| Morganella morganii | 1.92% | 0% | 2.45% | 0% |
| Proteus mirabilis | 1.83% | 0% | 1.32% | 0% |
| Providencia rettgeri | 0% | 0% | 2.55% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Pseudomonas aeruginosa | 0.15% | 0% | 0.04% | 0% |
| Raoultella planticola | 0% | 0% | 2.56% | 0% |
| Salmonella enterica | 0.06% | 0.77% | 0.25% | 0% |
| Serratia marcescens | 0% | 1.94% | 2.62% | 0% |
| Shigella boydii | 0% | 0% | 6.67% | 0% |
| Shigella dysenteriae | 0% | 0% | 3.33% | 0% |
| Shigella flexneri | 1% | 2.81% | 1.55% | 0% |
| Shigella sonnei | 9.76% | 6.8% | 2.19% | 0% |
| Vibrio cholerae | 0% | 0% | 0.13% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.21% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500