CTX-M beta-lactamase [AMR Gene Family]

Accession ARO:3000016
DefinitionThese enzymes were named for their greater activity against cefotaxime than other oxyimino-beta-lactam substrates (eg, ceftazidime, ceftriaxone, or cefepime). Rather than arising by mutation, they represent examples of plasmid acquisition of beta-lactamase genes normally found on the chromosome of Kluyvera species, a group of rarely pathogenic commensal organisms. These enzymes are not very closely related to TEM or SHV beta-lactamases in that they show only approximately 40% identity with these two commonly isolated beta-lactamases. Despite their name, a few are more active on ceftazidime than cefotaxime. CTX-M-15 was recently found in bacterial strains expressing NDM-1 and were responsible for resistance to aztreonam.
Drug Classcephalosporin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ class A beta-lactamase
Sub-Term(s)
160 ontology terms | Show
+ CTX-M-1
+ CTX-M-2
+ CTX-M-3
+ CTX-M-4
+ CTX-M-5
+ CTX-M-6
+ CTX-M-7
+ CTX-M-8
+ CTX-M-9
+ CTX-M-10
+ CTX-M-11
+ CTX-M-12
+ CTX-M-13
+ CTX-M-14
+ CTX-M-15
+ CTX-M-16
+ CTX-M-17
+ CTX-M-19
+ CTX-M-20
+ CTX-M-21
+ CTX-M-22
+ CTX-M-23
+ CTX-M-24
+ CTX-M-25
+ CTX-M-26
+ CTX-M-27
+ CTX-M-28
+ CTX-M-29
+ CTX-M-30
+ CTX-M-31
+ CTX-M-32
+ CTX-M-33
+ CTX-M-34
+ CTX-M-35
+ CTX-M-36
+ CTX-M-37
+ CTX-M-38
+ CTX-M-39
+ CTX-M-40
+ CTX-M-41
+ CTX-M-42
+ CTX-M-43
+ CTX-M-44
+ CTX-M-45
+ CTX-M-46
+ CTX-M-47
+ CTX-M-48
+ CTX-M-49
+ CTX-M-50
+ CTX-M-51
+ CTX-M-52
+ CTX-M-53
+ CTX-M-54
+ CTX-M-55
+ CTX-M-56
+ CTX-M-58
+ CTX-M-59
+ CTX-M-60
+ CTX-M-61
+ CTX-M-62
+ CTX-M-63
+ CTX-M-64
+ CTX-M-65
+ CTX-M-66
+ CTX-M-67
+ CTX-M-68
+ CTX-M-69
+ CTX-M-70
+ CTX-M-71
+ CTX-M-72
+ CTX-M-73
+ CTX-M-74
+ CTX-M-75
+ CTX-M-76
+ CTX-M-77
+ CTX-M-78
+ CTX-M-79
+ CTX-M-80
+ CTX-M-81
+ CTX-M-82
+ CTX-M-83
+ CTX-M-84
+ CTX-M-86
+ CTX-M-87
+ CTX-M-88
+ CTX-M-89
+ CTX-M-90
+ CTX-M-91
+ CTX-M-92
+ CTX-M-93
+ CTX-M-94
+ CTX-M-95
+ CTX-M-96
+ CTX-M-98
+ CTX-M-99
+ CTX-M-100
+ CTX-M-101
+ CTX-M-102
+ CTX-M-103
+ CTX-M-104
+ CTX-M-105
+ CTX-M-106
+ CTX-M-107
+ CTX-M-108
+ CTX-M-109
+ CTX-M-110
+ CTX-M-111
+ CTX-M-112
+ CTX-M-113
+ CTX-M-114
+ CTX-M-115
+ CTX-M-116
+ CTX-M-117
+ CTX-M-119
+ CTX-M-120
+ CTX-M-121
+ CTX-M-122
+ CTX-M-123
+ CTX-M-124
+ CTX-M-125
+ CTX-M-126
+ CTX-M-127
+ CTX-M-128
+ CTX-M-129
+ CTX-M-130
+ CTX-M-131
+ CTX-M-132
+ CTX-M-134
+ CTX-M-135
+ CTX-M-137
+ CTX-M-136
+ CTX-M-138
+ CTX-M-139
+ CTX-M-140
+ CTX-M-141
+ CTX-M-142
+ CTX-M-143
+ CTX-M-144
+ CTX-M-145
+ CTX-M-146
+ CTX-M-147
+ CTX-M-148
+ CTX-M-150
+ CTX-M-151
+ CTX-M-152
+ CTX-M-153
+ CTX-M-154
+ CTX-M-85
+ CTX-M-155
+ CTX-M-156
+ CTX-M-157
+ CTX-M-158
+ CTX-M-159
+ CTX-M-160
+ CTX-M-161
+ CTX-M-162
+ CTX-M-163
+ CTX-M-164
+ CTX-M-165
+ CTX-M-166
Publications

Kumarasamy KK, et al. 2010. Lancet Infect Dis 10(9): 597-602. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. (PMID 20705517)