hydrolysis of beta-lactam antibiotic by serine beta-lactamase

Accession ARO:3000187
DefinitionMechanism of enzymatic degradation common to Ambler Class A, C and D beta-lactamases. A serine residue located in the active site is used to form an acyl-enzyme intermediate and subsequent hydrolysis renders the beta-lactam inactive.
Resistance Mechanismantibiotic inactivation
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
3 ontology terms | Show
+ class A beta-lactamase participates_in
+ class C beta-lactamase participates_in
+ class D beta-lactamase participates_in