class C beta-lactamase

Accession ARO:3000076
Synonym(s)AmpC beta-lactamase
DefinitionAmpC type beta-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant Gram-negative bacteria. AmpC beta-lactamases (also termed class C or group 1) are typically encoded on the chromosome of many Gram-negative bacteria including Citrobacter, Serratia, Enterobacter species, and P. aeruginosa where its expression is usually inducible; it may also occur on Escherichia coli but is not usually inducible, although it can be hyperexpressed. AmpC type beta-lactamases may also be carried on plasmids. AmpC beta-lactamases, in contrast to ESBLs, hydrolyse broad and extended-spectrum cephalosporins (cephamycins as well as to oxyimino-beta-lactams) but are not inhibited by beta-lactamase inhibitors such as clavulanic acid.
Resistance Mechanismantibiotic inactivation
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
19 ontology terms | Show
+ ACC beta-lactamase [AMR Gene Family]
+ ACT beta-lactamase [AMR Gene Family]
+ DHA beta-lactamase [AMR Gene Family]
+ FOX beta-lactamase [AMR Gene Family]
+ MIR beta-lactamase [AMR Gene Family]
+ CMY-LAT-MOX beta-lactamase
+ OCH beta-lactamase [AMR Gene Family]
+ SRT beta-lactamase [AMR Gene Family]
+ PDC beta-lactamase [AMR Gene Family]
+ AQU beta-lactamase [AMR Gene Family]
+ ADC beta-lactamase without carbapenemase activity [AMR Gene Family]
+ ADC beta-lactamase with carbapenemase activity [AMR Gene Family]
+ CepS beta-lactamase [AMR Gene Family]
+ class C LRA beta-lactamase [AMR Gene Family]
+ ampC-type beta-lactamase [AMR Gene Family]
+ BUT beta-lactamase [AMR Gene Family]
+ TRU beta-lactamase [AMR Gene Family]
+ BIL Beta-lactamase [AMR Gene Family]
+ CMH beta-lactamase [AMR Gene Family]
Publications

Lister PD, et al. 2009. Clin. Microbiol. Rev. 22(4):582-610 Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. (PMID 19822890)