class C beta-lactamase

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000076
Synonym(s)AmpC beta-lactamase
DefinitionAmpC type beta-lactamases are commonly isolated from extended-spectrum cephalosporin-resistant Gram-negative bacteria. AmpC beta-lactamases (also termed class C or group 1) are typically encoded on the chromosome of many Gram-negative bacteria including Citrobacter, Serratia, Enterobacter species, and P. aeruginosa where its expression is usually inducible; it may also occur on Escherichia coli but is not usually inducible, although it can be hyperexpressed. AmpC type beta-lactamases may also be carried on plasmids. AmpC beta-lactamases, in contrast to ESBLs, hydrolyse broad and extended-spectrum cephalosporins (cephamycins as well as to oxyimino-beta-lactams) but are not inhibited by beta-lactamase inhibitors such as clavulanic acid.
Resistance Mechanismantibiotic inactivation
CARD:Epi text mining of PubMed up to 2021

(top ten associations if supported by more than one publication)
NCBI_TAXONEscherichia coli (60), Enterobacteriaceae (27), Pseudomonas aeruginosa (27), Klebsiella pneumoniae (21), Citrobacter freundii (15), Enterobacter cloacae (15), Enterobacter (9), Salmonella (7), Acinetobacter baumannii (6), Klebsiella (6)
GAZChina (4), Republic of China (2), Canadian (2)
FOODONchicken (2), meat (skinless) (2)
ENVOhospital (11), farm (2)
UBERONmembrane organ (6), feces (3), blood (3), renal system (3), zone of skin (2)
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
36 ontology terms | Show
+ ACC beta-lactamase [AMR Gene Family]
+ ACT beta-lactamase [AMR Gene Family]
+ DHA beta-lactamase [AMR Gene Family]
+ FOX beta-lactamase [AMR Gene Family]
+ MIR beta-lactamase [AMR Gene Family]
+ CMY-LAT-MOX beta-lactamase
+ OCH beta-lactamase [AMR Gene Family]
+ SRT beta-lactamase [AMR Gene Family]
+ PDC beta-lactamase [AMR Gene Family]
+ AQU beta-lactamase [AMR Gene Family]
+ CepS beta-lactamase [AMR Gene Family]
+ class C LRA beta-lactamase [AMR Gene Family]
+ ampC-type beta-lactamase [AMR Gene Family]
+ BUT beta-lactamase [AMR Gene Family]
+ TRU beta-lactamase [AMR Gene Family]
+ BIL Beta-lactamase [AMR Gene Family]
+ CMH beta-lactamase [AMR Gene Family]
+ IDC beta-lactamase [AMR Gene Family]
+ YRC beta-lactamase [AMR Gene Family]
+ PAC beta-lactamase [AMR Gene Family]
+ CMA beta-lactamase [AMR Gene Family]
+ CSA beta-lactamase [AMR Gene Family]
+ EC beta-lactamase [AMR Gene Family]
+ LHK beta-lactamase [AMR Gene Family]
+ MOR beta-lactamase [AMR Gene Family]
+ SST beta-lactamase [AMR Gene Family]
+ ADC beta-lactamase
+ PRC beta-lactamase [AMR Gene Family]
+ LAQ beta lactamase [AMR Gene Family]
+ PSZ beta-lactamase [AMR Gene Family]
+ CDA beta-lactamase [AMR Gene Family]
+ AMZ beta-lactamase [AMR Gene Family]
+ PNC beta-lactamase [AMR Gene Family]
+ RSC1 beta-lactamase [AMR Gene Family]
+ SFDC beta-lactamase [AMR Gene Family]
+ YOC beta-lactamase [AMR Gene Family]
Publications

Lister PD, et al. 2009. Clin. Microbiol. Rev. 22(4):582-610 Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. (PMID 19822890)
Curator Acknowledgements
Curator Description Most Recent Edit