AMZ beta-lactamase [AMR Gene Family]

Accession ARO:3007693
DefinitionThe AMZ genes showed resistance against some beta-lactam antibiotics, including amoxicillin and cephalothin, and the beta-lactamase AMZ-1 exhibited a similar substrate spectrum response. Similar to other AmpC beta-lactamases, AMZ-1 is strongly inhibited by avibactam but much less strongly inhibited by tazobactam.
Drug Classcephalosporin, penam
Resistance Mechanismantibiotic inactivation
Classification11 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ class C beta-lactamase
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
1 ontology terms | Show

Zhang Y, et al. 2023. Front Microbiol 14:1252427 Identification and characterization of a novel β-lactamase gene, blaAMZ-1, from Achromobacter mucicolens. (PMID 37808287)