| Accession | ARO:3004232 |
| Definition | AmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related. |
| Drug Class | cephalosporin, penam |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] + class C beta-lactamase |
| Sub-Term(s) | 4 ontology terms | Show |
| Publications | Esterly JS, et al. 2011. Ann Pharmacother 45(2):218-28 Genetic Mechanisms of Antimicrobial Resistance of Acinetobacter baumannii. (PMID 21304033) |