ampC-type beta-lactamase [AMR Gene Family]

Accession ARO:3004232
DefinitionAmpC beta-lactamases are clinically important class C beta-lactamase enzymes which confer resistance to cephalosporins and penicillin-like antibiotics. AmpC beta-lactamases are typically found in Enterobacteriaceae, and were described in Escherichia coli in 1940 as the first reported enzymatic deactivation of penicillin. The name AmpC connects these enzymes functionally across many species, however these enzymes are generally unnamed and not phylogenetically related.
Drug Classcephalosporin, penam
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ class C beta-lactamase
Sub-Term(s)
7 ontology terms | Show
Publications

Esterly JS, et al. 2011. Ann Pharmacother 45(2):218-28 Genetic Mechanisms of Antimicrobial Resistance of Acinetobacter baumannii. (PMID 21304033)