Rhodobacter sphaeroides ampC beta-lactamase

Accession ARO:3004291
CARD Short NameRsph_ampC_BLA
DefinitionA periplasmic cephalosporinase described in Rhodobacter sphaeroides shown to contribute to resistance of beta-lactam antibiotics.
AMR Gene FamilyampC-type beta-lactamase
Drug Classpenam, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification14 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic benzylpenicillin [Antibiotic]
+ ampC-type beta-lactamase [AMR Gene Family]
Publications

Baumann M, et al. 1989. J. Bacteriol. 171(1):308-13 Susceptibility of Rhodobacter sphaeroides to beta-lactam antibiotics: isolation and characterization of a periplasmic beta-lactamase (cephalosporinase). (PMID 2783689)

Resistomes

Prevalence of Rhodobacter sphaeroides ampC beta-lactamase among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|ABA81355.1|+|Rhodobacter sphaeroides ampC beta-lactamase [Cereibacter sphaeroides 2.4.1]
MKHLSPLSILLMVGALTPALAQDTTPSFESAAAAAFESVIEEHDIPGLVVGVTHGGRHSFYQTGLASREDQQPVTPDTLFELGSISKIFN
VTLAALAEERGALSLDAPVADYLPSLRGSPAGELTLIDLATHHTGGLPLQVPDEVADVDRLVDWLRSWRPPEPGTRSYSNISIGLLGHIT
AGVLGMSYADASQTVIFPALGLKSTWIDVPTDAMGRYAFGYDRKTDAPTRVTPGVLDDEAYGVKSSARDMLTLLDLELGTGTASPEVQTA
VATTQEGRFQTRLYTQAMIWEAYPWPVDPERLVEGNGYDFILQPQPVDEVDTTPDRRVILNKTGSTNGFGGYIAIVPSEDLGVVVLANRN
YPNEARVRATYDLITHILAE


>gb|CP000144.2|+|874561-875703|Rhodobacter sphaeroides ampC beta-lactamase [Cereibacter sphaeroides 2.4.1]
ATGAAGCACCTTTCCCCCCTCTCCATCCTGCTCATGGTGGGCGCGCTGACGCCCGCGCTTGCGCAAGACACCACGCCGTCGTTCGAGAGC
GCCGCCGCCGCGGCCTTCGAGAGCGTCATCGAGGAGCATGACATTCCCGGTCTGGTGGTGGGCGTGACCCACGGCGGACGGCACAGTTTC
TATCAGACAGGCTTGGCCTCACGGGAAGATCAGCAGCCGGTAACCCCTGACACGCTTTTTGAGCTCGGTTCGATCAGCAAGATCTTCAAC
GTGACGCTGGCGGCCTTGGCAGAGGAGCGGGGCGCGCTGTCGCTCGATGCGCCGGTCGCCGACTATCTTCCCTCCCTGCGAGGTTCTCCT
GCAGGAGAGCTGACGCTGATCGATCTGGCGACGCACCATACCGGCGGCCTCCCGTTGCAGGTGCCGGACGAAGTTGCAGATGTAGATCGC
CTGGTCGACTGGCTACGGAGTTGGCGACCGCCCGAGCCCGGTACGCGCAGCTATTCCAACATCAGCATCGGCCTATTGGGGCACATCACC
GCGGGCGTGCTGGGCATGAGCTATGCTGATGCGTCCCAGACGGTTATCTTCCCGGCGCTCGGATTGAAGAGCACGTGGATCGACGTCCCC
ACCGATGCGATGGGACGCTACGCCTTCGGCTATGACCGCAAGACAGACGCGCCAACCCGGGTTACGCCCGGCGTGCTGGACGATGAAGCG
TACGGGGTAAAATCCTCCGCTCGCGACATGCTGACGCTGCTCGACCTCGAGCTTGGAACCGGCACTGCCTCGCCCGAAGTTCAAACGGCG
GTGGCCACCACGCAGGAGGGCCGGTTCCAGACCCGCCTGTACACGCAGGCCATGATATGGGAGGCCTATCCTTGGCCTGTCGACCCAGAG
CGTCTGGTGGAGGGGAACGGGTATGACTTCATCCTCCAGCCTCAGCCTGTGGACGAGGTGGACACGACACCCGATCGGAGGGTCATCCTG
AACAAGACAGGTTCCACGAACGGCTTCGGTGGGTACATCGCGATCGTGCCAAGCGAGGATCTGGGCGTCGTCGTCCTTGCCAACCGCAAC
TACCCCAACGAGGCGCGGGTTCGAGCCACTTACGACCTGATCACTCACATCTTGGCCGAATAA