ACT beta-lactamase [AMR Gene Family]

Accession ARO:3000072
DefinitionACT beta-lactamases, also known as AmpC beta-lactamases, are cephalosporinases that cannot be inhibited by clavulanate. These enzymes are encoded by genes located on the chromosome and can be induced by the presence of beta-lactam antibiotics. However recently, these genes have been found on plasmids and expressed at high constitutive levels in Escherichia coli and Klebsiella pneumoniae.
Drug Classcephamycin, cephalosporin, penam, carbapenem
Resistance Mechanismantibiotic inactivation
Classification11 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ class C beta-lactamase
+ confers_resistance_to_drug_class cephamycin [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class carbapenem [Drug Class]
83 ontology terms | Show

Bradford PA, et al. 1997. Antimicrob Agents Chemother 41(3): 563-569. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein. (PMID 9055993)