azole antibiotic

Accession ARO:3007495
DefinitionAzoles are a group of antibiotics, particularly antifungals, that target the cytochrome P450 enzyme sterol 14alpha-demethylase, which converts lanosterol to ergosterol. They are typically fungistatic in yeasts and fungicidal in molds. The two main groups of azoles are imidazoles and triazoles.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ triazole antibiotic [Drug Class]
+ imidazole antibiotic [Drug Class]

Shafiei M, et al. 2020. Bioorg Chem 104:104240 History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action. (PMID 32906036)