CTX-M-8

Accession ARO:3001871
CARD Short NameCTX-M-8
DefinitionCTX-M-8 is a beta-lactamase found in the Enterobacteriaceae family.
AMR Gene FamilyCTX-M beta-lactamase
Drug Classcephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesCitrobacter freundiiwgs, Enterobacter kobeiwgs, Escherichia colip+wgs, Klebsiella michiganensisp, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Providencia stuartiiwgs, Salmonella entericawgs
Resistomes with Sequence VariantsCitrobacter freundiiwgs, Enterobacter kobeiwgs, Escherichia colip+wgs, Klebsiella michiganensisp, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Providencia stuartiiwgs, Salmonella entericawgs
Classification13 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ CTX-M beta-lactamase [AMR Gene Family]
Sub-Term(s)
2 ontology terms | Show
+ tazobactam [Adjuvant] is_small_molecule_inhibitor
+ clavulanic acid [Adjuvant] is_small_molecule_inhibitor
Publications

Bonnet R, et al. 2000. Antimicrob Agents Chemother 44(7): 1936-1942. A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil. (PMID 10858358)

Resistomes

Prevalence of CTX-M-8 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter freundii0%0%0.19%0%
Enterobacter kobei0%0%0.44%0%
Escherichia coli0%0.04%0.26%0%
Klebsiella michiganensis0%0.57%0%0%
Klebsiella pneumoniae0%0.01%0.12%0%
Klebsiella quasipneumoniae0%0%0.13%0%
Providencia stuartii0%0%2.27%0%
Salmonella enterica0%0%0.1%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AAF04388.1|+|CTX-M-8 [Citrobacter amalonaticus]
MMRHRVKRMMLMTTACISLLLGSAPLYAQANDVQQKLAALEKSSGGRLGVALIDTADNAQTLYRADERFAMCSTSKVMAAAAVLKQSETQ
KKVLSQKVEIKSSDLINYNPITEKHVNGTMTLAELSAAALQYSDNTAMNKLIAHLGGPDKVTAFARAIGDNTFRLDRTEPTLNTAIPGDP
RDTTTPLAMAQTLRNLTLGSALGETQRAQLVTWLKGNTTGAASIQAGLPTSWVVGDKTGSGDYGTTNDIAVIWPEGRAPLILVTYFTQPE
QKAESRRDVLAAAAKIVTDGY


>gb|AF189721.1|+|274-1149|CTX-M-8 [Citrobacter amalonaticus]
ATGATGAGACATCGCGTTAAGCGGATGATGCTAATGACAACGGCCTGTATTTCGCTGTTGCTGGGGAGTGCGCCGCTGTATGCGCAGGCG
AACGACGTTCAGCAAAAGCTGGCGGCGCTGGAGAAAAGCAGCGGGGGGCGGTTGGGAGTGGCGCTGATTGACACCGCCGATAACGCACAG
ACGCTCTACCGCGCCGATGAGCGCTTTGCCATGTGCAGCACCAGTAAGGTGATGGCGGCAGCGGCTGTGCTCAAGCAAAGTGAAACGCAA
AAGAAGGTGTTGAGTCAGAAGGTTGAGATTAAATCTTCAGACCTGATTAACTACAATCCCATTACTGAAAAACACGTCAACGGCACGATG
ACGCTGGCGGAATTGAGCGCCGCGGCGTTGCAGTACAGCGACAATACGGCCATGAACAAGCTGATTGCCCATCTTGGGGGGCCGGATAAA
GTGACGGCGTTTGCCCGTGCGATTGGGGATAACACCTTCCGGCTCGATCGTACTGAGCCGACGCTCAACACCGCGATCCCCGGCGACCCG
CGCGATACCACCACGCCATTAGCGATGGCGCAGACGCTTCGCAATCTGACGTTGGGCAGTGCCTTAGGTGAAACTCAGCGTGCGCAACTG
GTAACGTGGCTGAAAGGCAATACCACCGGCGCTGCCAGCATTCAGGCTGGGCTACCCACATCGTGGGTTGTCGGGGATAAAACCGGCAGC
GGTGATTATGGTACGACGAATGACATCGCCGTTATCTGGCCGGAAGGGCGTGCGCCGCTTATTCTGGTCACTTACTTCACCCAGCCAGAG
CAGAAGGCAGAAAGTCGTCGTGACGTACTCGCGGCTGCCGCGAAAATCGTCACCGACGGTTATTAA