ledaborbactam [Adjuvant]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3007298
Synonym(s)VNRX-5236
DefinitionLedaborbactam is an experimental boronic acid beta-lactamase inhibitor that has shown been show to inhibitor several serine beta-lactamases.
SMILESCCC(=O)N[C@H]1Cc2cccc(C(=O)O)c2OB1O
PubChem138455079
ChEMBLCHEMBL5093566
Classification5 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ is_small_molecule_inhibitor_of SHV-5
+ is_small_molecule_inhibitor_of CTX-M-15
+ is_small_molecule_inhibitor_of KPC-2
+ boronic acid beta-lactamase inhibitor
Publications

Chatwin CL, et al. 2021. Antimicrob Agents Chemother 65(8):e0055221 Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of Enterobacterales Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases. (PMID 34001510)

Curator Acknowledgements
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