SHV-5

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Accession ARO:3001064
Synonym(s)CAZ-4
CARD Short NameSHV-5
DefinitionSHV-5 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii, Enterobacter cloacae, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Salmonella enterica.
AMR Gene FamilySHV beta-lactamase
Drug Classpenicillin beta-lactam, cephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+wgs, Aeromonas hydrophilawgs, Citrobacter freundiip, Enterobacter asburiaewgs, Enterobacter cloacaep, Enterobacter hormaecheig+p+wgs, Enterobacter kobeiwgs, Escherichia coliwgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosawgs, Serratia marcescenswgs, Shigella sonneiwgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+wgs, Aeromonas hydrophilawgs, Citrobacter freundiip, Enterobacter asburiaewgs, Enterobacter cloacaep, Enterobacter hormaecheig+p+wgs, Enterobacter kobeiwgs, Escherichia coliwgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosawgs, Serratia marcescenswgs, Shigella sonneiwgs
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ SHV beta-lactamase [AMR Gene Family]
Sub-Term(s)
6 ontology terms | Show
+ tazobactam [Adjuvant] is_small_molecule_inhibitor
+ clavulanic acid [Adjuvant] is_small_molecule_inhibitor
+ vaborbactam [Adjuvant] is_small_molecule_inhibitor
+ taniborbactam [Adjuvant] is_small_molecule_inhibitor
+ ledaborbactam [Adjuvant] is_small_molecule_inhibitor
+ ledaborbactam etzadroxil [Adjuvant] is_small_molecule_inhibitor
Publications

Billot-Klein D, et al. 1990. Antimicrob Agents Chemother 34(12): 2439-2441. Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid. (PMID 2088203)
Resistomes

Prevalence of SHV-5 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Acinetobacter baumannii0.18%0%0.07%0%0%
Aeromonas hydrophila0%0%0.81%0%0%
Citrobacter freundii0%0.31%0%0%0%
Enterobacter asburiae0%0%1.19%0%0%
Enterobacter cloacae0%0.56%0%0%0%
Enterobacter hormaechei0.36%0.06%0.26%0%0%
Enterobacter kobei0%0%0.44%0%0%
Escherichia coli0%0%0.01%0%0%
Klebsiella michiganensis0%0%0.27%0%0%
Klebsiella pneumoniae0.3%0.06%0.3%0%0%
Klebsiella quasipneumoniae0.84%0.42%0.39%0%0%
Providencia stuartii0%0%2.27%0%0%
Pseudomonas aeruginosa0%0%0.2%0%0%
Serratia marcescens0%0%0.52%0%0%
Shigella sonnei0%0%0.07%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 550


>gb|CAA39164.1|+|SHV-5 [Klebsiella pneumoniae]
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERK
IHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPA
SMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASKRGARGIVALLGPNNKAERIVVIYLRDTPASMAERN
QQIAGIGAALIEHWQR


>gb|X55640.1|+|112-972|SHV-5 [Klebsiella pneumoniae]
ATGCGTTATATTCGCCTGTGTATTATCTCCCTGTTAGCCACCCTGCCGCTGGCGGTACACGCCAGCCCGCAGCCGCTTGAGCAAATTAAA
CTAAGCGAAAGCCAGCTGTCGGGCCGCGTAGGCATGATAGAAATGGATCTGGCCAGCGGCCGCACGCTGACCGCCTGGCGCGCCGATGAA
CGCTTTCCCATGATGAGCACCTTTAAAGTAGTGCTCTGCGGCGCAGTGCTGGCGCGGGTGGATGCCGGTGACGAACAGCTGGAGCGAAAG
ATCCACTATCGCCAGCAGGATCTGGTGGACTACTCGCCGGTCAGCGAAAAACACCTTGCCGACGGCATGACGGTCGGCGAACTCTGCGCC
GCCGCCATTACCATGAGCGATAACAGCGCCGCCAATCTGCTACTGGCCACCGTCGGCGGCCCCGCAGGATTGACTGCCTTTTTGCGCCAG
ATCGGCGACAACGTCACCCGCCTTGACCGCTGGGAAACGGAACTGAATGAGGCGCTTCCCGGCGACGCCCGCGACACCACTACCCCGGCC
AGCATGGCCGCGACCCTGCGCAAGCTGCTGACCAGCCAGCGTCTGAGCGCCCGTTCGCAACGGCAGCTGCTGCAGTGGATGGTGGACGAT
CGGGTCGCCGGACCGTTGATCCGCTCCGTGCTGCCGGCGGGCTGGTTTATCGCCGATAAGACCGGAGCTAGCAAGCGGGGTGCGCGCGGG
ATTGTCGCCCTGCTTGGCCCGAATAACAAAGCAGAGCGCATTGTGGTGATTTATCTGCGGGATACCCCGGCGAGCATGGCCGAGCGAAAT
CAGCAAATCGCCGGGATCGGCGCGGCGCTGATCGAGCACTGGCAACGCTAA

Curator Acknowledgements
Curator Description Most Recent Edit