SHV beta-lactamase [AMR Gene Family]

Accession ARO:3000015
DefinitionSHV-1 shares 68 percent of its amino acids with TEM-1 and has a similar overall structure. The SHV-1 beta-lactamase is most commonly found in K. pneumoniae and is responsible for up to 20% of the plasmid-mediated ampicillin resistance in this species. ESBLs in this family also have amino acid changes around the active site, most commonly at positions 238 or 238 and 240. More than 60 SHV varieties are known.
Drug Classcarbapenem, cephalosporin, penam
Resistance Mechanismantibiotic inactivation
Classification13 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ SHV-LEN beta-lactamase
Sub-Term(s)
187 ontology terms | Show
+ SHV-1
+ SHV-2
+ SHV-2A
+ SHV-3
+ SHV-4
+ SHV-5
+ SHV-6
+ SHV-7
+ SHV-8
+ SHV-9
+ SHV-10
+ SHV-11
+ SHV-12
+ SHV-13
+ SHV-14
+ SHV-15
+ SHV-16
+ SHV-18
+ SHV-19
+ SHV-20
+ SHV-21
+ SHV-22
+ SHV-23
+ SHV-24
+ SHV-25
+ SHV-26
+ SHV-27
+ SHV-28
+ SHV-29
+ SHV-30
+ SHV-31
+ SHV-32
+ SHV-33
+ SHV-34
+ SHV-35
+ SHV-36
+ SHV-37
+ SHV-38
+ SHV-39
+ SHV-40
+ SHV-41
+ SHV-42
+ SHV-43
+ SHV-44
+ SHV-45
+ SHV-46
+ SHV-48
+ SHV-49
+ SHV-50
+ SHV-51
+ SHV-52
+ SHV-53
+ SHV-55
+ SHV-56
+ SHV-57
+ SHV-59
+ SHV-60
+ SHV-61
+ SHV-62
+ SHV-63
+ SHV-64
+ SHV-65
+ SHV-66
+ SHV-67
+ SHV-69
+ SHV-70
+ SHV-71
+ SHV-72
+ SHV-73
+ SHV-74
+ SHV-75
+ SHV-76
+ SHV-77
+ SHV-78
+ SHV-79
+ SHV-80
+ SHV-81
+ SHV-82
+ SHV-83
+ SHV-84
+ SHV-85
+ SHV-86
+ SHV-89
+ SHV-90
+ SHV-91
+ SHV-92
+ SHV-93
+ SHV-94
+ SHV-95
+ SHV-96
+ SHV-97
+ SHV-101
+ SHV-102
+ SHV-103
+ SHV-104
+ SHV-105
+ SHV-106
+ SHV-107
+ SHV-108
+ SHV-109
+ SHV-110
+ SHV-111
+ SHV-112
+ SHV-113
+ SHV-114
+ SHV-115
+ SHV-116
+ SHV-117
+ SHV-120
+ SHV-121
+ SHV-122
+ SHV-123
+ SHV-124
+ SHV-125
+ SHV-126
+ SHV-127
+ SHV-128
+ SHV-129
+ SHV-133
+ SHV-134
+ SHV-135
+ SHV-137
+ SHV-140
+ SHV-141
+ SHV-142
+ SHV-145
+ SHV-147
+ SHV-148
+ SHV-149
+ SHV-150
+ SHV-151
+ SHV-152
+ SHV-153
+ SHV-154
+ SHV-155
+ SHV-156
+ SHV-157
+ SHV-158
+ SHV-159
+ SHV-160
+ SHV-161
+ SHV-162
+ SHV-163
+ SHV-165
+ SHV-167
+ SHV-54
+ SHV-58
+ SHV-68
+ SHV-87
+ SHV-88
+ SHV-98
+ SHV-99
+ SHV-100
+ SHV-118
+ SHV-119
+ SHV-132
+ SHV-138
+ SHV-139
+ SHV-143
+ SHV-144
+ SHV-146
+ SHV-164
+ SHV-166
+ SHV-174
+ SHV-180
+ SHV-183
+ SHV-168
+ SHV-169
+ SHV-170
+ SHV-171
+ SHV-172
+ SHV-173
+ SHV-175
+ SHV-176
+ SHV-177
+ SHV-178
+ SHV-179
+ SHV-181
+ SHV-182
+ SHV-184
+ SHV-185
+ SHV-186
+ SHV-187
+ SHV-188
+ SHV-189
+ SHV-190
+ SHV-191
Publications

Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791)