| Accession | ARO:3001060 |
| CARD Short Name | SHV-2 |
| Definition | SHV-2 is an extended-spectrum beta-lactamase found in E. coli., Klebsiella pneumoniae, and Shigella flexneri. |
| AMR Gene Family | SHV beta-lactamase |
| Drug Class | carbapenem, cephalosporin, penam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter werkmaniiwgs, Escherichia coliwgs, Klebsiella michiganensisp+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Raoultella planticolawgs, Salmonella entericawgs |
| Resistomes with Sequence Variants | Citrobacter werkmaniiwgs, Escherichia coliwgs, Klebsiella michiganensisp+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Raoultella planticolawgs, Salmonella entericawgs |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + antibiotic molecule + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + beta-lactamase + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + cephem + class A beta-lactamase + SHV-LEN beta-lactamase + carbapenem [Drug Class] + cephalosporin [Drug Class] + penam [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + SHV beta-lactamase [AMR Gene Family] |
| Sub-Term(s) | 4 ontology terms | Show + tazobactam [Adjuvant] is_small_molecule_inhibitor + clavulanic acid [Adjuvant] is_small_molecule_inhibitor + avibactam [Adjuvant] is_small_molecule_inhibitor + ARX1796 [Adjuvant] is_small_molecule_inhibitor |
| Publications | Bradford PA. 1999. Antimicrob Agents Chemother 43(12): 2960-2963. Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes. (PMID 10582889) Podbielski A, et al. 1991. J Gen Microbiol 137(3): 569-578. Molecular characterization of a new plasmid-encoded SHV-type beta-lactamase (SHV-2 variant) conferring high-level cefotaxime resistance upon Klebsiella pneumoniae. (PMID 2033379) |
Prevalence of SHV-2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Escherichia coli | 0% | 0% | 0.04% | 0% |
| Klebsiella michiganensis | 0% | 0.57% | 0.27% | 0% |
| Klebsiella pneumoniae | 0% | 0.01% | 0.18% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.39% | 0% |
| Raoultella planticola | 0% | 0% | 2.56% | 0% |
| Salmonella enterica | 0% | 0% | 0.02% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 550