| Accession | ARO:3001071 |
| Synonym(s) | SHV-5-2a |
| CARD Short Name | SHV-12 |
| Definition | SHV-12 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii. |
| AMR Gene Family | SHV beta-lactamase |
| Drug Class | penam, cephalosporin, carbapenem |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniip, Bacillus subtiliswgs, Citrobacter amalonaticuswgs, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Citrobacter youngaewgs, Cronobacter malonaticuswgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella aerogeneswgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+p+wgs, Morganella morganiiwgs, Proteus mirabiliswgs, Providencia stuartiip, Pseudomonas aeruginosawgs, Raoultella planticolap+wgs, Salmonella entericap+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniip, Bacillus subtiliswgs, Citrobacter amalonaticuswgs, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Citrobacter youngaewgs, Cronobacter malonaticuswgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella aerogeneswgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+p+wgs, Morganella morganiiwgs, Proteus mirabiliswgs, Providencia stuartiip, Pseudomonas aeruginosawgs, Raoultella planticolap+wgs, Salmonella entericap+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + beta-lactamase + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + cephem + class A beta-lactamase + penam [Drug Class] + cephalosporin [Drug Class] + SHV-LEN beta-lactamase + carbapenem [Drug Class] |
| Parent Term(s) | 4 ontology terms | Show + SHV beta-lactamase [AMR Gene Family] + confers_resistance_to_antibiotic cefalotin [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] |
| Sub-Term(s) | 1 ontology terms | Show + Xeruborbactam [Adjuvant] is_small_molecule_inhibitor |
| Publications | Nuesch-Inderbinen MT, et al. 1997. Antimicrob Agents Chemother 41(5): 943-949. Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12. (PMID 9145849) |
Prevalence of SHV-12 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0% | 0.17% | 0% |
| Aeromonas hydrophila | 0% | 1.3% | 0.81% | 0% |
| Aeromonas veronii | 0% | 1.54% | 0% | 0% |
| Bacillus subtilis | 0% | 0% | 0.29% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 3.64% | 0% |
| Citrobacter freundii | 0% | 1.23% | 4.64% | 0% |
| Citrobacter portucalensis | 0% | 0% | 9.01% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Enterobacter asburiae | 0% | 0.28% | 7.91% | 0% |
| Enterobacter chengduensis | 0% | 0% | 8% | 0% |
| Enterobacter cloacae | 0% | 3.91% | 4.79% | 0% |
| Enterobacter hormaechei | 0.36% | 4.25% | 12.56% | 0% |
| Enterobacter kobei | 0% | 2.76% | 9.61% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 3.6% | 0% |
| Escherichia coli | 0.02% | 0.1% | 0.5% | 0% |
| Escherichia fergusonii | 0% | 0% | 1.09% | 0% |
| Klebsiella aerogenes | 0% | 0% | 2.54% | 0% |
| Klebsiella michiganensis | 1.61% | 2.29% | 2.13% | 0% |
| Klebsiella oxytoca | 0% | 0% | 1.68% | 0% |
| Klebsiella pneumoniae | 2.13% | 2.47% | 4.77% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.27% | 5% | 0% |
| Leclercia adecarboxylata | 14.29% | 4.76% | 6.98% | 0% |
| Morganella morganii | 0% | 0% | 0.61% | 0% |
| Proteus mirabilis | 0% | 0% | 0.5% | 0% |
| Providencia stuartii | 0% | 6.82% | 0% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Raoultella planticola | 0% | 2.33% | 2.56% | 0% |
| Salmonella enterica | 0% | 0.05% | 0.19% | 0% |
| Serratia marcescens | 0% | 1.94% | 1.05% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 550