cefalotin [Antibiotic]

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Accession ARO:3000704
Synonym(s)CEF cephalothin
DefinitionCefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.
Drug Classcephalosporin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephalosporin [Drug Class]
Sub-Term(s)
23 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ SHV-12 confers_resistance_to_antibiotic
+ CTX-M-3 confers_resistance_to_antibiotic
+ OXA-1 confers_resistance_to_antibiotic
+ AcrAB-TolC confers_resistance_to_antibiotic
+ OXA-50 confers_resistance_to_antibiotic
+ TEM-1 confers_resistance_to_antibiotic
+ CTX-M-27 confers_resistance_to_antibiotic
+ CTX-M-15 confers_resistance_to_antibiotic
+ SCO-1 confers_resistance_to_antibiotic
+ CMY-2 confers_resistance_to_antibiotic
+ PDC-3 confers_resistance_to_antibiotic
+ PDC-5 confers_resistance_to_antibiotic
+ TEM-30 confers_resistance_to_antibiotic
+ LAP-1 confers_resistance_to_antibiotic
+ LAP-2 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae OmpK36 confers_resistance_to_antibiotic
+ MAB confers_resistance_to_antibiotic
+ blaC confers_resistance_to_antibiotic
+ Yrc-1 confers_resistance_to_antibiotic
+ TRU-1 confers_resistance_to_antibiotic
+ Sed-1 confers_resistance_to_antibiotic
Publications

KLEIN JO, et al. 1964. Am J Med Sci 248: 640-656. CEPHALOTHIN: ACTIVITY IN VITRO, ABSORPTION AND EXCRETION IN NORMAL SUBJECTS AND CLINICAL OBSERVATIONS IN 40 PATIENTS. (PMID 14251901)

Petersen SW and Rosin E. 1995. Vet Surg 24(4): 347-351. Cephalothin and cefazolin in vitro antibacterial activity and pharmacokinetics in dogs. (PMID 7571387)