cefalotin [Antibiotic]

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Accession ARO:3000704
Synonym(s)CEF cephalothin
DefinitionCefalotin is a semisynthetic cephalosporin antibiotic activate against staphylococci. It is resistant to staphylococci beta-lactamases but hydrolyzed by enterobacterial beta-lactamases.
Drug Classcephalosporin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephalosporin [Drug Class]
Sub-Term(s)
11 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ SHV-12 confers_resistance_to_antibiotic
+ CTX-M-3 confers_resistance_to_antibiotic
+ OXA-1 confers_resistance_to_antibiotic
+ AcrAB-TolC confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline confers_resistance_to_antibiotic
+ OXA-50 confers_resistance_to_antibiotic
+ TEM-1 confers_resistance_to_antibiotic
+ CTX-M-27 confers_resistance_to_antibiotic
+ CTX-M-15
Publications

KLEIN JO, et al. 1964. Am J Med Sci 248: 640-656. CEPHALOTHIN: ACTIVITY IN VITRO, ABSORPTION AND EXCRETION IN NORMAL SUBJECTS AND CLINICAL OBSERVATIONS IN 40 PATIENTS. (PMID 14251901)

Petersen SW and Rosin E. 1995. Vet Surg 24(4): 347-351. Cephalothin and cefazolin in vitro antibacterial activity and pharmacokinetics in dogs. (PMID 7571387)