Yrc-1

Accession ARO:3005035
CARD Short NameYrc-1
DefinitionYrc-1 is a ampC-like beta-lactamase that confers resistance to penams and cephalosporins. It is an ambler class C beta-lactamase.
AMR Gene FamilyYRC Beta-lactamase
Drug Classpenam, cephalosporin
Resistance Mechanismantibiotic inactivation
Classification14 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ confers_resistance_to_antibiotic cefoxitin [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic cefuroxime [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin [Antibiotic]
+ confers_resistance_to_antibiotic cefalotin [Antibiotic]
+ YRC Beta-lactamase [AMR Gene Family]
Publications

Mammeri H, et al. 2006. FEMS Microbiol. Lett. 257(1):57-62 Cloning and functional characterization of the ambler class C beta-lactamase of Yersinia ruckeri. (PMID 16553832)

Resistomes

Prevalence of Yrc-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 750


>gb|ABA70720.1|+|Yrc-1 [Yersinia ruckeri]
MMHKTLSCALLLVASGSTFATPQTEKKLSGIVDNVVIPLMKEQAIPGMAVAVIYQGQPYYFTWGMADVAGKQPVTQQTLFELGSVSKTFT
GVLGGDAIARGEIKLSDPVSKYWPALSGKQWEGISLLNLATYTAGGLPLQVPDNITDETSLQNYYETWQPQWAPGTKRFYSNASIGMFGK
LAVKPSGMSFEQAMNKRVFQPLNLTHTWIHVPEREEKHYAWGYRDGKAVHVSPGMLDAEAYGVKSSIKDMASWVRANMTPSEVKDASLQK
GILLAQSRYLQVGDMYQGLGWEMLNWPMKATIAVGGSDNKVALAPLSAVEINPPAPALNSSWVHKTGSTGGFGSYVAFIPEKNLGIVMLA
NKSYPNPARVEAAYRILEALSVE


>gb|DQ185144.1|+|381-1532|Yrc-1 [Yersinia ruckeri]
ATGATGCATAAAACCCTTTCCTGTGCGCTGCTGCTCGTCGCGTCAGGTTCCACGTTTGCCACGCCTCAAACGGAAAAAAAACTCAGTGGA
ATTGTTGATAACGTTGTTATTCCTTTGATGAAAGAACAGGCCATTCCCGGCATGGCGGTGGCGGTGATCTATCAGGGCCAACCTTACTAC
TTTACCTGGGGAATGGCTGATGTCGCAGGCAAACAGCCTGTTACGCAGCAGACGTTATTCGAGCTCGGCTCCGTGAGTAAAACCTTCACC
GGCGTGCTGGGTGGCGATGCCATTGCTCGTGGGGAAATTAAACTTAGTGATCCAGTGAGTAAATACTGGCCAGCGCTTTCCGGGAAACAA
TGGGAAGGGATTAGTTTGCTGAATTTGGCAACCTATACCGCTGGTGGCTTGCCGCTCCAGGTACCGGATAACATTACTGATGAGACGTCA
TTGCAGAATTACTATGAAACCTGGCAGCCACAGTGGGCTCCGGGCACCAAGCGTTTTTATTCAAACGCCAGTATTGGGATGTTTGGCAAA
CTGGCGGTTAAACCTTCAGGCATGAGCTTTGAGCAGGCGATGAACAAACGCGTGTTCCAGCCATTGAATCTCACGCATACTTGGATACAT
GTTCCTGAACGTGAAGAAAAACACTATGCGTGGGGCTATCGCGATGGGAAAGCCGTTCATGTTTCTCCGGGGATGCTGGACGCTGAAGCC
TACGGCGTGAAATCCTCAATAAAGGATATGGCAAGCTGGGTGCGGGCTAACATGACGCCTTCTGAAGTAAAAGATGCCTCGCTGCAAAAG
GGGATTTTGCTTGCCCAGTCGCGGTACTTGCAAGTGGGTGACATGTATCAGGGGTTGGGCTGGGAAATGCTGAACTGGCCGATGAAAGCA
ACAATCGCGGTCGGCGGTAGCGATAATAAAGTCGCACTCGCGCCGCTAAGTGCGGTAGAAATTAACCCGCCAGCGCCAGCATTAAATAGC
TCGTGGGTACATAAAACTGGCTCAACCGGCGGATTTGGAAGCTACGTGGCTTTCATTCCCGAGAAGAATCTCGGCATCGTGATGCTGGCG
AACAAAAGTTATCCTAACCCTGCGCGTGTCGAAGCAGCTTACCGCATCCTTGAAGCTTTGTCCGTGGAATAG