cefoxitin [Antibiotic]

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Accession ARO:0000008
Synonym(s)Cefoxitin Mefoxitin mefoxin FOX
DefinitionCefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases.
Drug Classcephamycin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephamycin [Drug Class]
Sub-Term(s)
13 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ CfxA confers_resistance_to_antibiotic
+ CAM-1 confers_resistance_to_antibiotic
+ Serratia marcescens Omp1 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae OmpK37 confers_resistance_to_antibiotic
+ Burkholderia pseudomallei Omp38 confers_resistance_to_antibiotic
+ CMY-42 confers_resistance_to_antibiotic
+ NDM-5 confers_resistance_to_antibiotic
+ NmcA confers_resistance_to_antibiotic
+ CMY-2 confers_resistance_to_antibiotic
+ cefoxitin-clavulanate has_part
+ cefoxitin-sulbactam has_part
+ cefoxitin-tazobactam has_part
Publications

Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804)

Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791)

Faraci WS and Pratt RF. 1986. Biochemistry 25(10): 2934-2941. Mechanism of inhibition of RTEM-2 beta-lactamase by cephamycins: relative importance of the 7 alpha-methoxy group and the 3' leaving group. (PMID 3487346)