blaC

Accession ARO:3007182
CARD Short NameblaC
DefinitionblaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs.
AMR Gene Familyclass A Mycobacterium tuberculosis bla beta-lactamase
Drug Classpenem, cephalosporin, cephamycin, penam
Resistance Mechanismantibiotic inactivation
Classification16 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ confers_resistance_to_antibiotic cefoxitin [Antibiotic]
+ confers_resistance_to_antibiotic amoxicillin [Antibiotic]
+ confers_resistance_to_antibiotic cefalotin [Antibiotic]
+ confers_resistance_to_antibiotic temocillin [Antibiotic]
+ confers_resistance_to_antibiotic ticarcillin [Antibiotic]
+ class A Mycobacterium tuberculosis bla beta-lactamase [AMR Gene Family]
Publications

Tremblay LW, et al. 2010. Biochemistry 49(17):3766-73 Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. (PMID 20353175)

Soroka D, et al. 2014. J Antimicrob Chemother 69(3):691-6 Characterization of broad-spectrum Mycobacterium abscessus class A β-lactamase. (PMID 24132992)

Resistomes

Prevalence of blaC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|CCP44842.1|-|blaC [Mycobacterium tuberculosis H37Rv]
MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPL
VAAVLHQNPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDA
EEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFPADWKVIDKTGTGDYGRANDIAVVWSPTG
VPYVVAVMSDRAGGGYDAEPREALLAEAATCVAGVLA


>gb|AL123456.3|-|2325886-2326809|blaC [Mycobacterium tuberculosis H37Rv]
ATGCGCAACAGAGGATTCGGTCGTCGCGAACTGCTGGTAGCGATGGCAATGCTGGTTTCCGTGACGGGGTGTGCACGGCATGCGAGCGGG
GCCCGTCCGGCATCGACAACCTTGCCGGCCGGAGCGGATCTGGCGGATCGCTTCGCCGAGCTGGAGCGCAGATACGATGCCCGGCTTGGG
GTGTATGTGCCCGCCACCGGCACCACCGCCGCGATCGAATACCGCGCCGATGAGCGGTTCGCATTCTGCTCCACGTTCAAGGCGCCGCTC
GTGGCGGCGGTGCTGCACCAAAACCCGCTCACGCATCTGGACAAACTGATCACCTACACCAGTGACGACATTCGGTCGATCTCCCCGGTG
GCCCAACAACACGTTCAGACCGGGATGACGATCGGGCAGCTTTGCGATGCGGCGATACGCTATAGCGACGGCACCGCCGCCAACCTGTTG
CTGGCCGATCTTGGCGGTCCCGGGGGCGGCACCGCGGCATTTACCGGCTACCTCCGCAGCTTGGGTGACACCGTGAGCCGGTTGGACGCC
GAGGAACCGGAGTTGAACCGCGATCCGCCCGGGGACGAACGGGATACCACAACACCGCACGCCATCGCCCTGGTGTTGCAGCAGCTTGTT
CTCGGCAACGCGTTGCCGCCCGACAAGCGGGCACTGCTCACCGATTGGATGGCGCGCAACACCACCGGAGCCAAGCGGATCCGAGCGGGC
TTTCCCGCCGATTGGAAGGTGATCGACAAGACCGGGACCGGTGACTACGGACGAGCAAACGACATCGCGGTCGTGTGGTCACCGACCGGC
GTGCCCTACGTGGTGGCCGTCATGTCCGATCGTGCCGGCGGCGGGTATGACGCCGAGCCCCGTGAGGCGCTGCTCGCCGAGGCGGCGACG
TGCGTTGCCGGTGTGCTTGCATAG