ticarcillin [Antibiotic]

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Accession ARO:3003832
Synonym(s)Ticarcilina Ticarcilline Ticarcillinum
DefinitionTicarcillin is a carboxypenicillin used for the treatment of Gram-negative bacteria, particularly P. aeruginosa. Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria try to divide, causing cell death.
Drug Classpenem
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ penem [Drug Class]
Sub-Term(s)
7 ontology terms | Show
+ ACI-1 confers_resistance_to_antibiotic
+ NDM-4 confers_resistance_to_antibiotic
+ MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ AdeIJK confers_resistance_to_antibiotic
+ SCO-1 confers_resistance_to_antibiotic
+ ticarcillin-clavulanic acid [Antibiotic] has_part
Publications

Mirzaagha P, et al. 2011. BMC Microbiol. 11:78 Distribution and characterization of ampicillin- and tetracycline-resistant Escherichia coli from feedlot cattle fed subtherapeutic antimicrobials. (PMID 21504594)

Nordmann P, et al. 2012. Antimicrob Agents Chemother 56(4): 2184-2186. NDM-4 metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli. (PMID 22252797)