| Accession | ARO:3004856 |
| Synonym(s) | A1E3K9 blaSCO-1 |
| CARD Short Name | SCO-1 |
| Definition | Narrow-spectrum beta-lactamase isolated from several Acinetobacter spp. isolates from Argentina, as well as E. Coli. Hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. |
| AMR Gene Family | SCO beta-lactamase |
| Drug Class | penem, penam, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig, Acinetobacter radioresistenswgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella michiganensiswgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus mirabiliswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Salmonella entericawgs, Shigella flexnerip |
| Resistomes with Sequence Variants | Acinetobacter baumanniig, Acinetobacter radioresistenswgs, Enterobacter cloacaep, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella michiganensiswgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus mirabiliswgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Salmonella entericawgs, Shigella flexnerip |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + penem [Drug Class] + class A beta-lactamase + penam [Drug Class] + cephalosporin [Drug Class] |
| Parent Term(s) | 10 ontology terms | Show + confers_resistance_to_antibiotic penicillin [Antibiotic] + confers_resistance_to_antibiotic cefepime [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic cefuroxime [Antibiotic] + confers_resistance_to_antibiotic amoxicillin [Antibiotic] + confers_resistance_to_antibiotic piperacillin [Antibiotic] + confers_resistance_to_antibiotic cefotaxime [Antibiotic] + confers_resistance_to_antibiotic cefalotin [Antibiotic] + confers_resistance_to_antibiotic ticarcillin [Antibiotic] + SCO beta-lactamase [AMR Gene Family] |
| Publications | Papagiannitsis CC, et al. 2011. Antimicrob. Agents Chemother. 55(1):376-81 Sequence of pR3521, an IncB plasmid from Escherichia coli encoding ACC-4, SCO-1, and TEM-1 beta-lactamases. (PMID 20956594) Poirel L, et al. 2007. Antimicrob. Agents Chemother. 51(6):2179-84 Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina. (PMID 17420213) Papagiannitsis CC, et al. 2007. Antimicrob Agents Chemother 51(6): 2185-2188. SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli. (PMID 17353248) |
Prevalence of SCO-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0% | 0% | 0% |
| Acinetobacter radioresistens | 0% | 0% | 3.51% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 0% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Escherichia coli | 0% | 0.01% | 0.01% | 0% |
| Klebsiella michiganensis | 0% | 0% | 0.27% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.13% | 0.69% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.39% | 0% |
| Morganella morganii | 0% | 0% | 0.61% | 0% |
| Proteus mirabilis | 0% | 0% | 0.17% | 0% |
| Providencia rettgeri | 0% | 0% | 0.64% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.07% | 0% |
| Salmonella enterica | 0% | 0% | 0.02% | 0% |
| Shigella flexneri | 0% | 0.4% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500
Type of Antibiotic Resistance: Acquired