piperacillin [Antibiotic]

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Accession ARO:0000078
Synonym(s)Pipercillin Piperacillin anhydrous Piperacillin sodium Pipracil Pipril
DefinitionPiperacillin is an acetylureidopenicillin and has an extended spectrum of targets relative to other beta-lactam antibiotics. It inhibits cell wall synthesis in bacteria, and is usually taken with the beta-lactamase inhibitor tazobactam to overcome penicillin-resistant bacteria.
Drug Classpenam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ penam [Drug Class]
15 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ Acinetobacter baumannii ampC beta-lactamase confers_resistance_to_antibiotic
+ OXA-1 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ SCO-1 confers_resistance_to_antibiotic
+ blaS1 confers_resistance_to_antibiotic
+ LAP-1 confers_resistance_to_antibiotic
+ LAP-2 confers_resistance_to_antibiotic
+ KBL-1 confers_resistance_to_antibiotic
+ TUS-1 confers_resistance_to_antibiotic
+ MUS-1 confers_resistance_to_antibiotic
+ MUS-2 confers_resistance_to_antibiotic
+ Sed-1 confers_resistance_to_antibiotic
+ piperacillin-sulbactam [Antibiotic+Adjuvant] has_part
+ piperacillin-tazobactam [Antibiotic+Adjuvant] has_part

Young M and Plosker GL. 2001. Pharmacoeconomics 19(11): 1135-1175. Piperacillin/tazobactam: a pharmacoeconomic review of its use in moderate to severe bacterial infections. (PMID 11735679)