KBL-1

Accession ARO:3007206
CARD Short NameKBL-1
DefinitionKBL-1 is a KBL class A beta-lactamase that confers resistance to a number of penicillin antibiotics.
AMR Gene FamilyKBL beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic amoxicillin [Antibiotic]
+ confers_resistance_to_antibiotic piperacillin [Antibiotic]
+ confers_resistance_to_antibiotic benzylpenicillin [Antibiotic]
+ confers_resistance_to_antibiotic ampicillin [Antibiotic]
+ KBL beta-lactamase [AMR Gene Family]
Publications

Kawauchi R, et al. 2022. Microbiol Spectr :e0114322 Stenotrophomonas maltophilia from Nepal Producing Two Novel Antibiotic Inactivating Enzymes, a Class A β-Lactamase KBL-1 and an Aminoglycoside 6'-N-Acetyltransferase AAC(6')-Iap. (PMID 35862995)

Resistomes

Prevalence of KBL-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 450


>gb|BCL63355.1|+|KBL-1 [Stenotrophomonas maltophilia]
MRLTFPFAAAVSILFALPLHAETVAEAARALEAELGGRIGVVLRAPEDDPLAVWRGDEAFPMASTFKVPLCGAVLARIDAGEEQAARILP
VETAALVEWSPVTEQQAGRGMSIADLCHATITMSDNTAANLLLDTVGGPAGLTAFLRDIGDATTRLDRTEPALNEALPEDMRDTTTPAAM
ADTLELLLFSELLSPEARAQLESWMRQDAVADDLLRASLPEGWMIGDKTGAGGNGSRSIIAVLRGPAGEPWLATVYMTQTGGDMDKRNAA
IARIGAAMIGEIQARR


>gb|LC579778.1|+|1-861|KBL-1 [Stenotrophomonas maltophilia]
ATGCGTCTTACATTTCCCTTCGCGGCGGCGGTTTCGATCCTGTTCGCGCTTCCCCTCCATGCCGAAACCGTGGCCGAAGCCGCCCGCGCG
CTCGAGGCCGAACTCGGCGGCCGGATCGGTGTCGTTCTGCGCGCTCCCGAAGACGATCCTTTGGCGGTCTGGCGCGGCGACGAAGCCTTT
CCCATGGCCAGCACCTTCAAGGTGCCGCTTTGCGGCGCGGTCCTTGCGCGGATCGATGCGGGCGAAGAGCAAGCGGCGCGGATCCTGCCG
GTCGAAACCGCCGCTCTGGTCGAATGGTCGCCGGTCACCGAACAGCAGGCGGGCCGCGGGATGAGCATTGCCGATCTCTGCCATGCCACG
ATCACCATGAGCGACAATACCGCCGCCAATCTTCTGCTCGACACGGTCGGCGGGCCTGCCGGTCTGACCGCTTTCCTGCGCGATATCGGC
GATGCGACGACGCGGCTCGACCGCACCGAACCGGCGCTGAACGAGGCCCTGCCCGAGGATATGCGCGACACGACGACGCCGGCGGCGATG
GCCGACACGCTGGAGCTTCTGCTGTTTTCCGAACTCCTCTCGCCCGAGGCGCGGGCGCAGCTTGAAAGCTGGATGCGGCAGGATGCCGTC
GCCGACGACCTGCTGCGCGCGAGCCTGCCCGAGGGCTGGATGATCGGCGACAAGACCGGCGCGGGCGGCAACGGTTCGCGCTCGATCATC
GCCGTCCTTCGGGGACCGGCGGGCGAGCCTTGGCTGGCGACCGTCTACATGACGCAAACCGGCGGGGATATGGACAAGCGCAACGCGGCC
ATTGCCCGCATCGGCGCGGCCATGATCGGCGAAATCCAAGCAAGGCGCTAA