| Accession | ARO:3001396 |
| Synonym(s) | OXA-30 |
| CARD Short Name | OXA-1 |
| Definition | OXA-1 is a beta-lactamase found in E. coli. |
| AMR Gene Family | OXA beta-lactamase, OXA-1-like beta-lactamase |
| Drug Class | penam, cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p, Aeromonas veroniig, Avibacterium paragallinarumg+wgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisg+p+wgs, Citrobacter werkmaniiwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella aerogenesp+wgs, Klebsiella huaxiensisg, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Morganella morganiig+p+wgs, Proteus mirabilisg+p+wgs, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella boydiiwgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+p+wgs, Shigella sonneiwgs, Vibrio choleraewgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p, Aeromonas veroniig, Avibacterium paragallinarumg+wgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisg+p+wgs, Citrobacter werkmaniiwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella aerogenesp+wgs, Klebsiella huaxiensisg, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Morganella morganiig+p+wgs, Pasteurella multocidag, Proteus mirabilisg+p+wgs, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella boydiiwgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+p+wgs, Shigella sonneiwgs, Vibrio choleraewgs |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + hydrolysis of antibiotic conferring resistance + antibiotic inactivation enzyme + beta-lactam antibiotic + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + penam [Drug Class] + beta-lactamase + oxacillin [Antibiotic] + cephem + class D beta-lactamase + cephalosporin [Drug Class] + OXA beta-lactamase [AMR Gene Family] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic piperacillin [Antibiotic] + confers_resistance_to_antibiotic amoxicillin [Antibiotic] + confers_resistance_to_antibiotic cefalotin [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + OXA-1-like beta-lactamase [AMR Gene Family] |
| Sub-Term(s) | 4 ontology terms | Show + SYN-1012 [Adjuvant] is_small_molecule_inhibitor + avibactam [Adjuvant] is_small_molecule_inhibitor + taniborbactam [Adjuvant] is_small_molecule_inhibitor + ARX1796 [Adjuvant] is_small_molecule_inhibitor |
| Publications | Ouellette M, et al. 1987. Proc Natl Acad Sci U S A 84(21): 7378-7382. Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene. (PMID 2823258) Tsang KK, et al. 2021. Microb Genom 7(1): Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance. (PMID 33416461) |
Prevalence of OXA-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.04% | 0% |
| Aeromonas caviae | 6.82% | 2.6% | 11.83% | 0% |
| Aeromonas hydrophila | 1.54% | 1.3% | 0% | 0% |
| Aeromonas veronii | 1.82% | 0% | 0% | 0% |
| Avibacterium paragallinarum | 12.5% | 0% | 2.94% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 5.45% | 0% |
| Citrobacter freundii | 0.82% | 5.85% | 11.41% | 0% |
| Citrobacter koseri | 0% | 15% | 6.31% | 0% |
| Citrobacter portucalensis | 3.7% | 14.71% | 17.12% | 0% |
| Citrobacter werkmanii | 0% | 0% | 25.64% | 0% |
| Enterobacter asburiae | 0% | 0.83% | 3.95% | 0% |
| Enterobacter chengduensis | 0% | 0% | 16% | 0% |
| Enterobacter cloacae | 1.79% | 1.68% | 10.86% | 0% |
| Enterobacter hormaechei | 1.8% | 1.61% | 10.53% | 0% |
| Enterobacter kobei | 0% | 0.69% | 3.93% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 1.08% | 0% |
| Escherichia coli | 1.07% | 0.53% | 4.75% | 0% |
| Escherichia fergusonii | 0% | 0% | 1.09% | 0% |
| Klebsiella aerogenes | 0% | 5.43% | 3.11% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 0% |
| Klebsiella michiganensis | 0% | 9.14% | 6.38% | 0% |
| Klebsiella oxytoca | 2.56% | 3.42% | 2.94% | 0% |
| Klebsiella pneumoniae | 4.67% | 3.13% | 15.2% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.48% | 11.05% | 0% |
| Morganella morganii | 23.08% | 2.5% | 9.82% | 0% |
| Pasteurella multocida | 0.71% | 0% | 0% | 0% |
| Proteus mirabilis | 27.52% | 6.25% | 6.93% | 0% |
| Proteus penneri | 0% | 0% | 25% | 0% |
| Providencia alcalifaciens | 18.18% | 0% | 0% | 0% |
| Providencia rettgeri | 8.82% | 0% | 3.18% | 0% |
| Providencia stuartii | 0% | 0% | 6.82% | 0% |
| Pseudomonas aeruginosa | 0.61% | 2.63% | 0.28% | 0% |
| Raoultella planticola | 0% | 6.98% | 15.38% | 0% |
| Salmonella enterica | 1.01% | 3.12% | 0.88% | 0% |
| Serratia marcescens | 0% | 1.29% | 3.15% | 0% |
| Shigella boydii | 0% | 0% | 5.56% | 0% |
| Shigella dysenteriae | 7.14% | 0% | 16.67% | 0% |
| Shigella flexneri | 38% | 1.2% | 66.46% | 0% |
| Shigella sonnei | 0% | 0% | 7.16% | 0% |
| Vibrio cholerae | 0% | 0% | 0.13% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500