OXA beta-lactamase [AMR Gene Family]

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Accession ARO:3000017
DefinitionOXA beta-lactamases were long recognized as a less common but also plasmid-mediated beta-lactamase variety that could hydrolyze oxacillin and related anti-staphylococcal penicillins. These beta-lactamases differ from the TEM and SHV enzymes in that they belong to molecular class D and functional group 2d. The OXA-type beta-lactamases confer resistance to ampicillin and cephalothin and are characterized by their high hydrolytic activity against oxacillin and cloxacillin and the fact that they are poorly inhibited by clavulanic acid. Amino acid substitutions in OXA enzymes can also give the ESBL phenotype. The OXA beta-lactamase family was originally created as a phenotypic rather than a genotypic group for a few beta-lactamases that had a specific hydrolysis profile. Therefore, there is as little as 20% sequence homology among some of the members of this family. However, recent additions to this family show some degree of homology to one or more of the existing members of the OXA beta-lactamase family. Some confer resistance predominantly to ceftazidime, but OXA-17 confers greater resistance to cefotaxime and cefepime than it does resistance to ceftazidime.
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Classification11 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ class D beta-lactamase
+ confers_resistance_to_antibiotic oxacillin [Antibiotic]
Sub-Term(s)
125 ontology terms | Show
+ OXA-6
+ OXA-8
+ OXA-16
+ OXA-18
+ OXA-20
+ OXA-29
+ OXA-33
+ OXA-34
+ OXA-36
+ OXA-37
+ OXA-38
+ OXA-39
+ OXA-41
+ OXA-44
+ OXA-52
+ OXA-116
+ OXA-140
+ OXA-220
+ OXA-221
+ OXA-222
+ OXA-227
+ OXA-238
+ OXA-258
+ OXA-310
+ OXA-311
+ OXA-318
+ OXA-319
+ OXA-321
+ OXA-367
+ OXA-393
+ OXA-394
+ OXA-399
+ OXA-410
+ OXA-243
+ OXA-186
+ OXA-187
+ OXA-188
+ OXA-189
+ OXA-190
+ OXA-191
+ OXA-102
+ OXA-105
+ OXA-279
+ OXA-289
+ OXA-290
+ OXA-296
+ OXA-299
+ OXA-308
+ OXA-347
+ OXA-85
+ OXA-45
+ OXA-209
+ OXA-428
+ OXA-434
+ OXA-419
+ OXA-445
+ OXA-456
+ OXA-457
+ OXA-458
+ OXA-459
+ OXA-462
+ OXA-463
+ OXA-464
+ OXA-467
+ OXA-468
+ OXA-469
+ OXA-481
+ OXA-487
+ OXA-665
+ OXA-664
+ OXA-837
+ OXA-926
+ OXA-491
+ OXA-504
+ OXA-527
+ OXA-542
+ OXA-568
+ OXA-576
+ OXA-666
+ OXA-732
+ OXA-780
+ OXA-830
+ OXA-900
+ OXA-919
+ OXA-925
+ OXA-1-like beta-lactamase [AMR Gene Family]
+ OXA-10-like beta-lactamase [AMR Gene Family]
+ OXA-114-like beta-lactamase [AMR Gene Family]
+ OXA-12-like beta-lactamase [AMR Gene Family]
+ OXA-134-like beta-lactamase [AMR Gene Family]
+ OXA-143-like beta-lactamase [AMR Gene Family]
+ OXA-184-like beta-lactamase [AMR Gene Family]
+ OXA-198-like beta-lactamase [AMR Gene Family]
+ OXA-2-like beta-lactamase [AMR Gene Family]
+ OXA-211-like beta-lactamase [AMR Gene Family]
+ OXA-213-like beta-lactamase [AMR Gene Family]
+ OXA-214-like beta-lactamase [AMR Gene Family]
+ OXA-22-like beta-lactamase [AMR Gene Family]
+ OXA-229-like beta-lactamase [AMR Gene Family]
+ OXA-23-like beta-lactamase [AMR Gene Family]
+ OXA-24-like beta-lactamase [AMR Gene Family]
+ OXA-266-like beta-lactamase [AMR Gene Family]
+ OXA-274-like beta-lactamase [AMR Gene Family]
+ OXA-286-like beta-lactamase [AMR Gene Family]
+ OXA-294-like beta-lactamase [AMR Gene Family]
+ OXA-364-like beta-lactamase [AMR Gene Family]
+ OXA-372-like beta-lactamase [AMR Gene Family]
+ OXA-42-like beta-lactamase [AMR Gene Family]
+ OXA-427-like beta-lactamase [AMR Gene Family]
+ OXA-46-like beta-lactamase [AMR Gene Family]
+ OXA-48-like beta-lactamase [AMR Gene Family]
+ OXA-493-like beta-lactamase [AMR Gene Family]
+ OXA-5-like beta-lactamase [AMR Gene Family]
+ OXA-50-like beta-lactamase [AMR Gene Family]
+ OXA-51-like beta-lactamase [AMR Gene Family]
+ OXA-548-like beta-lactamase [AMR Gene Family]
+ OXA-55-like beta-lactamase [AMR Gene Family]
+ OXA-58-like beta-lactamase [AMR Gene Family]
+ OXA-60-like beta-lactamase [AMR Gene Family]
+ OXA-61-like beta-lactamase [AMR Gene Family]
+ OXA-62-like beta-lactamase [AMR Gene Family]
+ OXA-63-like beta-lactamase [AMR Gene Family]
+ OXA-679-like beta-lactamase [AMR Gene Family]
+ OXA-727-like beta-lactamase [AMR Gene Family]
+ OXA-9-like beta-lactamase [AMR Gene Family]
Publications

Turton JF, et al. 2006. J Clin Microbiol 44(8): 2974-2976. Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species. (PMID 16891520)

Evans BA, et al. 2014. Clin Microbiol Rev 27(2): 241-263. OXA beta-Lactamases. (PMID 24696435)