OXA-243

Accession ARO:3001610
CARD Short NameOXA-243
DefinitionOXA-243 is a beta-lactamase found in Achromobacter xylosoxidans.
AMR Gene FamilyOXA beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsAchromobacter xylosoxidansg, Burkholderia cepaciag
Classification13 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ OXA beta-lactamase [AMR Gene Family]
Publications

Amoureux L, et al. 2013. J Cyst Fibros 12(2): 170-176. Epidemiology and resistance of Achromobacter xylosoxidans from cystic fibrosis patients in Dijon, Burgundy: First French data. (PMID 22944724)

Resistomes

Prevalence of OXA-243 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Achromobacter xylosoxidans4.35%0%0%0%
Burkholderia cepacia1.82%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AFQ90085.1|+|OXA-243 [Achromobacter xylosoxidans]
MTVRLSSTALGAALSLSALAGAPAQAAVLCTVVADAADGRIVYQQGTQQACAARYTPASTFKLPIALMGADAGILTGPHAPVWNYQPGYP
DWGGDAWRQPTDPARWIKYSVVWYSQLTARALGQERFQRYASAFHYGNEDVSGEPGKHNGLDGAWINSSLRISPLEQLAFLRKLVNRQLP
LKAAAYDLAENLFEVGEAGGWHLYGKTGTGSPGSNGVYTAANAYGWFVGWARKDGRQLVFARLVQDEQATKPNAGLRARDDLMRDWPAMA
DAPRK


>gb|JX206446.1|+|1-828|OXA-243 [Achromobacter xylosoxidans]
ATGACCGTTCGCCTCTCTTCGACCGCTCTCGGCGCGGCCCTTTCCCTGTCCGCGCTGGCCGGCGCCCCCGCCCAGGCGGCCGTCCTGTGC
ACCGTGGTGGCCGACGCCGCCGACGGCCGCATCGTGTACCAGCAGGGCACGCAGCAGGCCTGCGCCGCGCGCTACACGCCGGCCTCGACC
TTCAAGCTGCCCATCGCCCTGATGGGCGCGGACGCCGGCATCCTGACGGGCCCGCACGCGCCGGTCTGGAACTACCAGCCCGGCTACCCC
GACTGGGGCGGCGACGCCTGGCGCCAGCCCACGGATCCGGCGCGCTGGATCAAGTATTCGGTGGTCTGGTATTCGCAGCTGACCGCCCGG
GCGCTGGGGCAGGAACGCTTCCAGCGCTATGCCTCGGCCTTCCATTACGGCAACGAGGACGTCTCGGGCGAACCCGGCAAACACAACGGC
CTGGACGGCGCATGGATCAACTCGTCGCTGCGGATTTCTCCGTTGGAACAACTGGCGTTCTTGCGCAAGCTGGTCAACCGGCAATTGCCG
CTCAAGGCGGCGGCCTACGACCTGGCCGAGAACCTGTTCGAGGTCGGCGAAGCCGGCGGCTGGCACCTGTATGGCAAGACCGGCACCGGC
TCGCCTGGCAGCAACGGCGTCTACACGGCGGCCAACGCCTACGGCTGGTTCGTCGGCTGGGCACGCAAGGACGGCCGCCAGCTGGTGTTC
GCCCGCCTGGTGCAGGACGAGCAGGCCACCAAGCCCAACGCCGGCCTGCGCGCCCGCGACGACCTGATGCGCGACTGGCCCGCCATGGCC
GACGCGCCGCGCAAGTAA