OXA-48-like beta-lactamase [AMR Gene Family]

Accession ARO:3007721
DefinitionOXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins.
AMR Gene FamilyOXA beta-lactamase
Drug Classpenam, carbapenem
Resistance Mechanismantibiotic inactivation
Classification13 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ OXA beta-lactamase [AMR Gene Family]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class carbapenem [Drug Class]
43 ontology terms | Show

Hirvonen VHA, et al. 2021. Antimicrob Agents Chemother 65(6): Antimicrobial Resistance Conferred by OXA-48 β-Lactamases: Towards a Detailed Mechanistic Understanding. (PMID 33753332)