Accession | ARO:3007721 |
Definition | OXA-48-type beta-lactamases are now routinely encountered in bacterial infections caused by carbapenam-resistant Enterobacterales. OXA-48-like proteins confer resistance to penicillin (which is efficiently hydrolyzed) and carbapenam antibiotics (which is more slowly broken down). The spectrum of activity of these variants varies, with some hydrolyzing expanded-spectrum oxyimino-cephalosporins. |
AMR Gene Family | OXA beta-lactamase |
Drug Class | penam, carbapenem |
Resistance Mechanism | antibiotic inactivation |
Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + penam [Drug Class] + beta-lactamase + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + oxacillin [Antibiotic] + class D beta-lactamase |
Parent Term(s) | 3 ontology terms | Show + OXA beta-lactamase [AMR Gene Family] + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_drug_class carbapenem [Drug Class] |
Sub-Term(s) | 43 ontology terms | Show + OXA-405 + OXA-370 + OXA-232 + OXA-416 + OXA-247 + OXA-244 + OXA-163 + OXA-54 + OXA-204 + OXA-48 + OXA-181 + OXA-245 + OXA-436 + OXA-484 + OXA-439 + OXA-438 + OXA-535 + OXA-505 + OXA-515 + OXA-514 + OXA-566 + OXA-538 + OXA-517 + OXA-546 + OXA-547 + OXA-793 + OXA-788 + OXA-924 + OXA-918 + OXA-922 + OXA-923 + OXA-894 + OXA-920 + OXA-1039 + OXA-1038 + OXA-567 + OXA-199 + OXA-252 + OXA-519 + OXA-929 + OXA-731 + OXA-162 + OXA-833 |
Publications | Hirvonen VHA, et al. 2021. Antimicrob Agents Chemother 65(6): Antimicrobial Resistance Conferred by OXA-48 β-Lactamases: Towards a Detailed Mechanistic Understanding. (PMID 33753332) |