OXA-837

Accession ARO:3005060
CARD Short NameOXA-837
DefinitionA class D OXA-like beta-lactamase described in the emerging pathogen Cupriavidus gilardii.
AMR Gene FamilyOXA beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Classification13 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ OXA beta-lactamase [AMR Gene Family]
Publications

Ruiz C, et al. 2019. mSphere 4(5): Comparative Genomics Reveals a Well-Conserved Intrinsic Resistome in the Emerging Multidrug-Resistant Pathogen Cupriavidus gilardii. (PMID 31578249)

Resistomes

Prevalence of OXA-837 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|QEE23059.1|+|OXA-837 [Cupriavidus gilardii]
MKSRTEAQSLHAHGLYRRRLLQLAGGAALLPAARLALADVAPASAVAAPSEVARGDLMSHFRALDVDGCFALFDVKANRMTLVNASRAKT
RMVPASTYKIPNSLIAFETGVVADPDQIQPYGGGKTRFPQWQRDMNLREAIAMSNVPVYQGIARRIGMQRMQTWVDRLDYGNRQLGKVVD
QFWLRGPLAISAAEQTRFLARLAQGQLPASRLSQQWVREILRVEANDDHAIYAKTGWAMDAGLNHGWWVGWVERSGGVHAFALNMDLQRE
ELAPKRMAIARAMMAELGVLPVENGQARKMS


>gb|MN313890.1|+|1-906|OXA-837 [Cupriavidus gilardii]
ATGAAGTCCCGTACCGAAGCGCAGTCCCTGCACGCGCATGGCCTGTATCGCCGCCGCCTGCTGCAACTGGCCGGCGGCGCCGCGCTGCTG
CCTGCCGCGCGCCTGGCGCTGGCCGATGTCGCGCCGGCAAGCGCCGTCGCCGCGCCGAGCGAAGTCGCCCGCGGTGATTTGATGTCGCAC
TTTCGCGCGCTGGACGTCGACGGCTGTTTTGCGCTGTTCGACGTCAAGGCGAACCGGATGACGCTGGTCAACGCATCGCGTGCGAAGACG
CGCATGGTGCCGGCGTCGACCTACAAGATTCCGAACAGCCTGATCGCCTTCGAGACCGGCGTGGTGGCCGATCCGGACCAGATCCAGCCA
TATGGCGGCGGCAAGACGCGCTTCCCGCAGTGGCAGCGCGACATGAATCTGCGCGAGGCGATCGCGATGTCGAATGTGCCGGTCTACCAG
GGCATTGCCCGGCGGATCGGCATGCAGCGGATGCAGACGTGGGTCGACCGGCTCGACTATGGCAACCGGCAACTCGGGAAGGTGGTGGAT
CAGTTCTGGCTGCGCGGGCCGCTGGCGATCTCGGCGGCCGAACAGACGCGCTTTCTGGCGCGGCTGGCACAGGGCCAACTACCGGCGTCG
CGCCTGAGCCAGCAATGGGTGCGCGAGATCCTGCGCGTCGAAGCCAATGACGATCACGCGATCTACGCCAAGACGGGCTGGGCGATGGAT
GCCGGGCTGAACCACGGCTGGTGGGTGGGGTGGGTCGAACGCAGCGGCGGCGTCCATGCCTTCGCGCTCAATATGGATCTGCAGCGCGAG
GAACTGGCGCCAAAGCGCATGGCCATCGCACGGGCGATGATGGCGGAACTTGGCGTGTTGCCCGTGGAGAACGGGCAAGCGCGCAAGATG
AGCTAG