Klebsiella pneumoniae KpnGH-TolC

Accession ARO:3004598
DefinitionDisruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classpeptide antibiotic, aminoglycoside antibiotic, macrolide antibiotic, cephalosporin, carbapenem, penam, fluoroquinolone antibiotic, penem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification20 ontology terms | Show
Parent Term(s)19 ontology terms | Show
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ confers_resistance_to_antibiotic polymyxin B3 [Antibiotic]
+ confers_resistance_to_antibiotic polymyxin B4 [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ confers_resistance_to_antibiotic ceftazidime [Antibiotic]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic ertapenem [Antibiotic]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic gentamicin C [Antibiotic]
+ confers_resistance_to_antibiotic polymyxin B1 [Antibiotic]
+ confers_resistance_to_antibiotic imipenem [Antibiotic]
+ confers_resistance_to_antibiotic ticarcillin [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic piperacillin [Antibiotic]
+ confers_resistance_to_antibiotic polymyxin B2 [Antibiotic]
+ confers_resistance_to_antibiotic spectinomycin [Antibiotic]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ confers_resistance_to_antibiotic streptomycin [Antibiotic]
Sub-Term(s)
3 ontology terms | Show
Publications

Srinivasan VB, et al. 2014. PLoS ONE 9(5):e96288 Role of novel multidrug efflux pump involved in drug resistance in Klebsiella pneumoniae. (PMID 24823362)