| Accession | ARO:3004598 |
| Definition | Disruption of the pump components KpnGH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | peptide antibiotic, aminoglycoside antibiotic, penem, penam, cephalosporin, carbapenem, fluoroquinolone antibiotic, macrolide antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 21 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + lipopeptide antibiotic + beta-lactam antibiotic + mechanism of antibiotic resistance + antibiotic mixture + cephem + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + polymyxin antibiotic + aminoglycoside antibiotic [Drug Class] + gentamicin [Antibiotic] + penem [Drug Class] + polymyxin B [Antibiotic] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + penam [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] |
| Parent Term(s) | 19 ontology terms | Show + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic gentamicin C [Antibiotic] + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic spectinomycin [Antibiotic] + confers_resistance_to_antibiotic streptomycin [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ertapenem [Antibiotic] + confers_resistance_to_antibiotic piperacillin [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic imipenem [Antibiotic] + confers_resistance_to_antibiotic polymyxin B1 [Antibiotic] + confers_resistance_to_antibiotic polymyxin B2 [Antibiotic] + confers_resistance_to_antibiotic polymyxin B3 [Antibiotic] + confers_resistance_to_antibiotic polymyxin B4 [Antibiotic] + confers_resistance_to_antibiotic norfloxacin [Antibiotic] + confers_resistance_to_antibiotic ticarcillin [Antibiotic] |
| Sub-Term(s) | 3 ontology terms | Show |
| Publications | Srinivasan VB, et al. 2014. PLoS ONE 9(5):e96288 Role of novel multidrug efflux pump involved in drug resistance in Klebsiella pneumoniae. (PMID 24823362) |