polymyxin antibiotic

Accession ARO:0000022
DefinitionPolymyxins are cationic detergent antibiotics, with a general structure of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins have a bactericidal effect on Gram-negative bacilli, especially on Pseudomonas and coliform organisms.
Drug Classpeptide antibiotic
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
12 ontology terms | Show
+ colistin
+ polymyxin B
+ polymyxin B4 [Antibiotic]
+ colistin B [Antibiotic]
+ colistin A [Antibiotic]
+ polymyxin B1 [Antibiotic]
+ polymyxin B2 [Antibiotic]
+ polymyxin B3 [Antibiotic]
+ cell membrane component targeted by antibiotic targeted_by
+ determinant of polymyxin resistance confers_resistance_to_drug_class
+ MCR-3.3 confers_resistance_to_antibiotic
+ MCR-9.1 confers_resistance_to_antibiotic

Breazeale SD, et al. 2002. J Biol Chem 277(4): 2886-2896. Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose. (PMID 11706007)