colistin A [Antibiotic]

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Accession ARO:3000622
Synonym(s)polymyxin E1
DefinitionColistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.
SMILESN/A
PubChem202195
Drug Classpeptide antibiotic
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
125 ontology terms | Show
+ cell membrane component targeted by antibiotic targeted_by_antibiotic
+ LpxD confers_resistance_to_antibiotic
+ ICR-Mo confers_resistance_to_antibiotic
+ LpxC confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ LpxA confers_resistance_to_antibiotic
+ Acinetobacter mutant Lpx gene conferring resistance to colistin [AMR Gene Family] confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ Klebsiella mutant PhoP conferring antibiotic resistance to colistin confers_resistance_to_antibiotic
+ Pseudomonas mutant PhoQ conferring resistance to colistin confers_resistance_to_antibiotic
+ Pseudomonas mutant PhoP conferring resistance to colistin confers_resistance_to_antibiotic
+ MCR phosphoethanolamine transferase [AMR Gene Family] confers_resistance_to_antibiotic
+ ICR-Mc confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ MCR-9.1 confers_resistance_to_antibiotic
+ MCR-3.3 confers_resistance_to_antibiotic
+ MCR-1.33 confers_resistance_to_antibiotic
+ mcr-10.1 confers_resistance_to_antibiotic
+ LpsB confers_resistance_to_antibiotic
+ eptB confers_resistance_to_antibiotic
+ MCR-1.1 confers_resistance_to_antibiotic
+ MCR-1.10 confers_resistance_to_antibiotic
+ MCR-1.11 confers_resistance_to_antibiotic
+ MCR-1.12 confers_resistance_to_antibiotic
+ MCR-1.13 confers_resistance_to_antibiotic
+ MCR-1.2 confers_resistance_to_antibiotic
+ MCR-1.3 confers_resistance_to_antibiotic
+ MCR-1.4 confers_resistance_to_antibiotic
+ MCR-1.5 confers_resistance_to_antibiotic
+ MCR-1.6 confers_resistance_to_antibiotic
+ MCR-1.7 confers_resistance_to_antibiotic
+ MCR-1.8 confers_resistance_to_antibiotic
+ MCR-1.9 confers_resistance_to_antibiotic
+ MCR-2.1 confers_resistance_to_antibiotic
+ MCR-2.2 confers_resistance_to_antibiotic
+ MCR-3.1 confers_resistance_to_antibiotic
+ MCR-3.10 confers_resistance_to_antibiotic
+ MCR-3.11 confers_resistance_to_antibiotic
+ MCR-3.12 confers_resistance_to_antibiotic
+ MCR-3.2 confers_resistance_to_antibiotic
+ MCR-3.4 confers_resistance_to_antibiotic
+ MCR-3.5 confers_resistance_to_antibiotic
+ MCR-3.6 confers_resistance_to_antibiotic
+ MCR-3.7 confers_resistance_to_antibiotic
+ MCR-3.8 confers_resistance_to_antibiotic
+ MCR-3.9 confers_resistance_to_antibiotic
+ MCR-4.1 confers_resistance_to_antibiotic
+ MCR-4.2 confers_resistance_to_antibiotic
+ MCR-4.3 confers_resistance_to_antibiotic
+ MCR-4.4 confers_resistance_to_antibiotic
+ MCR-4.5 confers_resistance_to_antibiotic
+ MCR-5.1 confers_resistance_to_antibiotic
+ MCR-5.2 confers_resistance_to_antibiotic
+ MCR-6.1 confers_resistance_to_antibiotic
+ MCR-7.1 confers_resistance_to_antibiotic
+ MCR-8.1 confers_resistance_to_antibiotic
+ MCR-3.41 confers_resistance_to_antibiotic
+ ArnT confers_resistance_to_antibiotic
+ Klebsiella pneumoniae mutant PhoQ conferring resistance to colistin confers_resistance_to_antibiotic
+ almEFG confers_resistance_to_antibiotic
+ MCR-1.14 confers_resistance_to_antibiotic
+ MCR-1.15 confers_resistance_to_antibiotic
+ MCR-1.16 confers_resistance_to_antibiotic
+ MCR-1.17 confers_resistance_to_antibiotic
+ MCR-1.18 confers_resistance_to_antibiotic
+ MCR-1.19 confers_resistance_to_antibiotic
+ MCR-1.20 confers_resistance_to_antibiotic
+ MCR-1.21 confers_resistance_to_antibiotic
+ MCR-1.22 confers_resistance_to_antibiotic
+ MCR-1.23 confers_resistance_to_antibiotic
+ MCR-1.24 confers_resistance_to_antibiotic
+ MCR-1.25 confers_resistance_to_antibiotic
+ MCR-1.26 confers_resistance_to_antibiotic
+ MCR-1.27 confers_resistance_to_antibiotic
+ MCR-1.28 confers_resistance_to_antibiotic
+ MCR-1.29 confers_resistance_to_antibiotic
+ MCR-1.30 confers_resistance_to_antibiotic
+ MCR-1.31 confers_resistance_to_antibiotic
+ MCR-1.32 confers_resistance_to_antibiotic
+ MCR-1.34 confers_resistance_to_antibiotic
+ MCR-10.2 confers_resistance_to_antibiotic
+ MCR-10.3 confers_resistance_to_antibiotic
+ MCR-10.4 confers_resistance_to_antibiotic
+ MCR-10.5 confers_resistance_to_antibiotic
+ MCR-2.3 confers_resistance_to_antibiotic
+ MCR-2.4 confers_resistance_to_antibiotic
+ MCR-2.5 confers_resistance_to_antibiotic
+ MCR-2.6 confers_resistance_to_antibiotic
+ MCR-2.7 confers_resistance_to_antibiotic
+ MCR-2.8 confers_resistance_to_antibiotic
+ MCR-3.13 confers_resistance_to_antibiotic
+ MCR-3.14 confers_resistance_to_antibiotic
+ MCR-3.15 confers_resistance_to_antibiotic
+ MCR-3.16 confers_resistance_to_antibiotic
+ MCR-3.17 confers_resistance_to_antibiotic
+ MCR-3.18 confers_resistance_to_antibiotic
+ MCR-3.19 confers_resistance_to_antibiotic
+ MCR-3.20 confers_resistance_to_antibiotic
+ MCR-3.21 confers_resistance_to_antibiotic
+ MCR-3.22 confers_resistance_to_antibiotic
+ MCR-3.23 confers_resistance_to_antibiotic
+ MCR-3.24 confers_resistance_to_antibiotic
+ MCR-3.25 confers_resistance_to_antibiotic
+ MCR-3.26 confers_resistance_to_antibiotic
+ MCR-3.27 confers_resistance_to_antibiotic
+ MCR-3.28 confers_resistance_to_antibiotic
+ MCR-3.29 confers_resistance_to_antibiotic
+ MCR-3.31 confers_resistance_to_antibiotic
+ MCR-3.32 confers_resistance_to_antibiotic
+ MCR-3.33 confers_resistance_to_antibiotic
+ MCR-3.34 confers_resistance_to_antibiotic
+ MCR-3.35 confers_resistance_to_antibiotic
+ MCR-3.36 confers_resistance_to_antibiotic
+ MCR-3.37 confers_resistance_to_antibiotic
+ MCR-3.38 confers_resistance_to_antibiotic
+ MCR-3.39 confers_resistance_to_antibiotic
+ MCR-3.40 confers_resistance_to_antibiotic
+ MCR-4.6 confers_resistance_to_antibiotic
+ MCR-5.3 confers_resistance_to_antibiotic
+ MCR-5.4 confers_resistance_to_antibiotic
+ MCR-8.2 confers_resistance_to_antibiotic
+ MCR-8.3 confers_resistance_to_antibiotic
+ MCR-8.4 confers_resistance_to_antibiotic
+ MCR-4.7 confers_resistance_to_antibiotic
+ mgrB confers_resistance_to_antibiotic
Publications

Michalopoulos AS and Karatza DC. 2010. Expert Rev Anti Infect Ther 8(9): 1009-1017. Multidrug-resistant Gram-negative infections: the use of colistin. (PMID 20818945)

Jansson B, et al. 2009. J Pharm Biomed Anal 49(3): 760-767. Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS. (PMID 19157746)
Curator Acknowledgements
Curator Description Most Recent Edit