colistin A [Antibiotic]

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Accession ARO:3000622
Synonym(s)polymyxin E1
DefinitionColistin A, or polymyxin E1, has a 6-octanoic acid lipid tail. Polymyxins disrupt the cell membrane of Gram-negative bacteria.
Drug Classpeptide antibiotic
Classification5 ontology terms | Show
Parent Term(s)1 ontology terms | Show
5 ontology terms | Show
+ cell membrane component targeted by antibiotic targeted_by_drug
+ ICR-Mo confers_resistance_to_drug
+ Pseudomonas mutant PhoP conferring resistance to colistin confers_resistance_to_drug
+ MCR phosphoethanolamine transferase [AMR Gene Family] confers_resistance_to_drug
+ ICR-Mc confers_resistance_to_drug

Michalopoulos AS and Karatza DC. 2010. Expert Rev Anti Infect Ther 8(9): 1009-1017. Multidrug-resistant Gram-negative infections: the use of colistin. (PMID 20818945)

Jansson B, et al. 2009. J Pharm Biomed Anal 49(3): 760-767. Quantitative analysis of colistin A and colistin B in plasma and culture medium using a simple precipitation step followed by LC/MS/MS. (PMID 19157746)