MCR-2.2

Accession ARO:3004502
DefinitionAn MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in Great Britain
AMR Gene FamilyMCR phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification15 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ evolutionary_variant_of MCR-2.1
+ MCR phosphoethanolamine transferase [AMR Gene Family]
Publications

AbuOun M, et al. 2017. J. Antimicrob. Chemother. 72(10):2745-2749 mcr-1 and mcr-2 variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015. (PMID 29091227)

Poirel L, et al. 2017. J. Antimicrob. Chemother. 72(10):2947-2949 MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium. (PMID 29091193)

Resistomes

Prevalence of MCR-2.2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1000


>gb|ASK49941.1|+|MCR-2.2 [Moraxella pluranimalium]
MTSQHSWYRYSINPFVLMGLVALFLAATANLTFFEKAMAVYPVSDNLGFIISMAVALMGAMLLIVVLLSYRYVLKPVLILLLIMGAVTSY
FTDTYGTVYDTTMLQNAMQTDQAESKDLMNLAFFVRIIGLGVLPSVLVAFAKVNYPTWGKGLIQRAMTWGVSLVLLLVPIGLFSSQYASF
FRVHKPVRFYINPITPIYSVGKLASIEYKKATAPTDTIYHAKDAVQTTKPSERKPRLVVFVVGETARADHVQFNGYGRETFPQLAKVDGL
ANFSQVTSCGTSTAYSVPCMFSYLGQDDYDVDTAKYQENVLDTLDRLGVDILWRDNNSDSKGVMDKLPTTQYFDYKSATNNTICNTNPFN
ECRDVGMLVGLDDYVSANNGKDMLIMLHQMGNHGPAYFKRYDEQFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAKSIDWLKTH
EANYDVAMLYVSDHGESLGENGVYLHGMPNAFAPKEQRAVPAFFWSNNTTFKPTASDTVLTHDAITPTLLKLFDVTADKVKDRTAFIQ


>gb|MF176239.1|+|1-1617|MCR-2.2 [Moraxella pluranimalium]
ATGACATCACAGCACTCTTGGTATCGCTACTCCATCAATCCTTTTGTACTGATGGGTTTGGTGGCGTTATTTTTGGCGGCAACAGCGAAC
CTGACATTTTTTGAAAAAGCGATGGCGGTCTATCCTGTATCGGATAACTTAGGCTTTATCATCTCAATGGCGGTTGCACTGATGGGTGCT
ATGCTATTGATTGTCGTGCTATTATCCTATCGCTATGTGCTAAAGCCTGTGCTGATTTTATTACTTATCATGGGTGCGGTGACGAGCTAT
TTTACCGATACTTATGGCACGGTCTATGATACCACCATGCTCCAAAATGCCATGCAAACCGACCAAGCTGAATCTAAAGACTTGATGAAT
TTGGCGTTTTTTGTGCGGATTATCGGGCTTGGCGTGTTGCCAAGTGTGTTGGTCGCATTTGCCAAAGTCAATTATCCAACATGGGGCAAA
GGCCTGATTCAGCGTGCGATGACGTGGGGTGTCAGCCTTGTGCTGTTGCTTGTGCCGATTGGGCTATTTAGCAGTCAGTATGCGAGTTTC
TTTCGGGTGCATAAGCCAGTGCGTTTTTATATCAATCCGATTACGCCGATTTATTCGGTGGGCAAGCTTGCCAGTATCGAGTACAAAAAA
GCCACTGCACCAACAGACACCATCTATCATGCCAAAGATGCCGTGCAGACCACCAAGCCTAGCGAGCGTAAGCCACGCCTAGTAGTGTTC
GTCGTCGGTGAGACGGCGCGTGCTGACCATGTGCAGTTCAATGGCTATGGCCGTGAGACTTTCCCACAGCTTGCCAAAGTTGATGGCTTG
GCGAATTTTAGCCAAGTGACATCGTGTGGCACATCGACAGCGTATTCTGTGCCGTGTATGTTTAGCTATTTGGGTCAAGATGACTATGAT
GTCGATACCGCCAAATACCAAGAAAATGTGCTAGATACGCTTGACCGCTTGGGCGTGGATATCTTGTGGCGTGATAATAATTCAGACTCA
AAAGGCGTGATGGATAAGCTACCTACCACGCAGTATTTTGATTATAAATCAGCGACCAACAACACCATCTGTAACACCAATCCCTTTAAT
GAATGCCGTGATGTCGGTATGCTTGTTGGGCTAGATGACTATGTCAGTGCCAATAATGGCAAAGATATGCTCATCATGCTACACCAAATG
GGCAATCATGGGCCGGCGTACTTTAAGCGTTATGATGAGCAATTTGCCAAATTCACCCCTGTGTGCGAAGGCAATGAGCTTGCCAAATGC
GAACACCAATCACTCATCAATGCCTATGATAATGCACTACTTGCCACCGATGATTTTATCGCCAAAAGTATCGATTGGCTAAAAACACAT
GAAGCAAACTACGATGTCGCTATGCTCTATGTCAGCGACCACGGCGAGAGCTTGGGCGAGAATGGTGTCTATCTGCATGGTATGCCAAAT
GCCTTTGCACCAAAAGAACAGCGAGCCGTGCCTGCGTTTTTTTGGTCAAATAATACGACATTCAAGCCAACTGCCAGCGACACTGTGCTG
ACGCATGATGCGATTACCCCGACATTGCTTAAGCTGTTTGATGTCACAGCCGACAAGGTCAAAGACCGCACGGCATTTATCCAGTAA