MCR phosphoethanolamine transferase [AMR Gene Family]

Accession ARO:3004268
DefinitionA group of mobile colistin resistance genes encode the MCR family of phosphoethanolamine transferases, which catalyze the addition of phosphoethanolamine onto lipid A, thus interfering with the binding of colistin to the cell membrane.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification11 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ phosphoethanolamine transferase conferring colistin resistance
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
105 ontology terms | Show

Liu YY, et al. 2015. Lancet Infect Dis : Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. (PMID 26603172)

Sun J, et al. 2017. MBio 8(3): Deciphering MCR-2 Colistin Resistance. (PMID 28487432)

Yin W, et al. 2017. MBio 8(3): Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli. (PMID 28655818)

Di Pilato V, et al. 2016. Antimicrob. Agents Chemother. 60(9):5612-5 mcr-1.2, a New mcr Variant Carried on a Transferable Plasmid from a Colistin-Resistant KPC Carbapenemase-Producing Klebsiella pneumoniae Strain of Sequence Type 512. (PMID 27401575)