Accession | ARO:3004268 |
Definition | A group of mobile colistin resistance genes encode the MCR family of phosphoethanolamine transferases, which catalyze the addition of phosphoethanolamine onto lipid A, thus interfering with the binding of colistin to the cell membrane. |
Drug Class | peptide antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + peptide antibiotic [Drug Class] + antibiotic target alteration [Resistance Mechanism] + lipopeptide antibiotic + charge alteration conferring antibiotic resistance + polymyxin antibiotic + determinant of antibiotic resistance + colistin + gene altering cell wall charge |
Parent Term(s) | 4 ontology terms | Show + phosphoethanolamine transferase conferring colistin resistance + confers_resistance_to_drug_class peptide antibiotic [Drug Class] + confers_resistance_to_antibiotic colistin A [Antibiotic] + confers_resistance_to_antibiotic colistin B [Antibiotic] |
Sub-Term(s) | 104 ontology terms | Show + MCR-9.1 + MCR-1.8 + MCR-1.11 + MCR-3.4 + MCR-3.11 + MCR-6.1 + MCR-3.3 + MCR-2.2 + MCR-1.5 + MCR-3.6 + MCR-3.10 + MCR-3.5 + MCR-1.10 + MCR-1.9 + MCR-3.9 + MCR-3.8 + MCR-3.7 + MCR-3.2 + MCR-1.6 + MCR-1.1 + MCR-2.1 + MCR-3.1 + MCR-1.2 + MCR-1.3 + MCR-1.4 + MCR-8.1 + MCR-4.1 + MCR-5.1 + MCR-7.1 + MCR-1.7 + MCR-1.12 + MCR-1.13 + MCR-3.12 + MCR-4.2 + MCR-4.3 + MCR-4.4 + MCR-4.5 + MCR-5.2 + MCR-3.41 + MCR-1.33 + mcr-10.1 + MCR-8.3 + MCR-8.4 + MCR-8.2 + MCR-1.34 + MCR-4.6 + MCR-1.27 + MCR-1.18 + MCR-1.23 + MCR-1.20 + MCR-1.28 + MCR-1.21 + MCR-1.16 + MCR-1.22 + MCR-1.19 + MCR-1.29 + MCR-1.30 + MCR-1.24 + MCR-1.17 + MCR-1.31 + MCR-1.14 + MCR-1.25 + MCR-3.33 + MCR-3.14 + MCR-3.37 + MCR-3.38 + MCR-3.15 + MCR-3.27 + MCR-3.32 + MCR-3.31 + MCR-3.23 + MCR-3.36 + MCR-3.25 + MCR-3.22 + MCR-3.16 + MCR-3.26 + MCR-3.21 + MCR-3.18 + MCR-3.40 + MCR-3.24 + MCR-3.20 + MCR-3.35 + MCR-3.34 + MCR-3.13 + MCR-3.28 + MCR-3.39 + MCR-3.29 + MCR-3.19 + MCR-10.5 + MCR-10.3 + MCR-10.4 + MCR-10.2 + MCR-3.17 + MCR-1.15 + MCR-1.26 + MCR-5.4 + MCR-5.3 + MCR-2.4 + MCR-2.3 + MCR-2.8 + MCR-2.5 + MCR-2.7 + MCR-2.6 + MCR-1.32 |
Publications | Liu YY, et al. 2015. Lancet Infect Dis : Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. (PMID 26603172) Sun J, et al. 2017. MBio 8(3): Deciphering MCR-2 Colistin Resistance. (PMID 28487432) Yin W, et al. 2017. MBio 8(3): Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli. (PMID 28655818) Di Pilato V, et al. 2016. Antimicrob. Agents Chemother. 60(9):5612-5 mcr-1.2, a New mcr Variant Carried on a Transferable Plasmid from a Colistin-Resistant KPC Carbapenemase-Producing Klebsiella pneumoniae Strain of Sequence Type 512. (PMID 27401575) |