MCR-6.1

Accession ARO:3004501
CARD Short NameMCR-6.1
DefinitionAn MCR-2 phosphoethanolamine transferase and polymyxin resistance gene variant identified in Moraxella isolated from pigs in the United Kingdom.
AMR Gene FamilyMCR phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification14 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ MCR phosphoethanolamine transferase [AMR Gene Family]
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
Publications

AbuOun M, et al. 2018. J. Antimicrob. Chemother. 73(10):2904 mcr-1 and mcr-2 (mcr-6.1) variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015. (PMID 30053008)

Resistomes

Prevalence of MCR-6.1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1000


>gb|ASK49942.1|+|MCR-6.1 [Moraxella sp. MSG47-C17]
MTQHSPWYRRPVNPYLLMSVVALFLSATANLTFFDKITNTYPMAQNAGFVISTALVLFGAMLLITVLLSYRYVLKPVLILLLIMGAVTSY
FTDTYGTVYDTTMLQNALQTDQAESKDLMNMAFFVRIIGLGVLPSILVAWVKVDYPTLGKSLIQRAMTWGVAVVMALVPILAFSSHYASF
FREHKPLRSYVNPVMPIYSVGKLASIEYKKATAPKDTIYHAKDAVQTTTPAERKPRLVVFVVGETARADHVQFNGYSRETFPQLAKIDNL
ANFSQVTSCGTSTAYSVPCMFSYLGQDDYDVDTAKYQENVLDTLDRLGVGILWRDNNSDSKGVMDKLPASQYFDYKSATNNTICNTNPYN
ECRDVGMLVGLDDYVSTNQGKDMLIMLHQMGNHGPAYFKRYDEQFAKYTPVCEGNELAKCEHQSLINAYDNALLATDDFIAKSIDWLKTH
QANYDVAMLYVSDHGESLGENGVYLHGMPNAFAPKEQRAVPAFFWSNNPSFTPTASDTVLTHDAITPTLLKLFDVTADKVKDRTAFIR


>gb|MF176240.1|+|1-1617|MCR-6.1 [Moraxella sp. MSG47-C17]
ATGACACAGCATAGTCCTTGGTACCGCCGTCCGGTCAATCCCTATCTGTTGATGAGCGTGGTCGCTTTATTTTTGTCAGCGACAGCAAAC
CTAACTTTCTTTGATAAAATCACCAATACTTATCCGATGGCACAAAACGCAGGCTTTGTGATCTCAACGGCGCTTGTGCTATTTGGGGCG
ATGCTATTGATTACTGTGCTGTTATCGTATCGCTATGTGCTTAAGCCTGTGTTGATTTTGCTGCTTATCATGGGTGCGGTGACGAGCTAT
TTTACCGATACTTATGGCACCGTTTATGACACCACCATGCTCCAAAATGCCTTGCAAACTGACCAAGCCGAGTCTAAGGACTTGATGAAT
ATGGCGTTTTTTGTGCGGATTATCGGGCTTGGCGTGTTGCCAAGTATCTTGGTGGCGTGGGTCAAGGTGGATTATCCGACATTGGGTAAG
AGTCTGATTCAGCGTGCGATGACTTGGGGTGTGGCAGTGGTGATGGCACTTGTGCCGATTTTGGCATTTAGTAGTCACTACGCCAGTTTC
TTTCGTGAACATAAGCCACTGCGTAGCTATGTCAATCCCGTGATGCCGATTTATTCAGTAGGTAAGCTTGCCAGTATTGAGTACAAAAAA
GCCACCGCGCCAAAAGACACCATCTATCATGCCAAAGATGCTGTACAGACGACGACGCCTGCCGAGCGTAAGCCACGACTCGTGGTGTTC
GTCGTCGGTGAGACGGCTCGAGCTGACCATGTGCAGTTTAATGGCTATAGTCGTGAGACTTTTCCGCAGCTTGCCAAGATTGACAACCTA
GCCAATTTTAGCCAAGTGACATCGTGTGGCACATCGACGGCGTACTCTGTGCCGTGTATGTTCAGTTATCTGGGTCAAGATGACTATGAT
GTCGATACCGCCAAATACCAAGAAAACGTGCTGGATACGCTTGACCGACTGGGTGTGGGTATCCTGTGGCGGGATAATAATTCAGACTCA
AAAGGCGTGATGGATAAACTGCCTGCTTCGCAGTATTTTGATTATAAATCAGCGACCAACAACACCATCTGTAACACCAATCCTTACAAC
GAATGTCGTGATGTCGGTATGTTGGTGGGGCTAGATGATTATGTGAGTACCAATCAAGGCAAAGATATGCTCATCATGCTACACCAAATG
GGTAATCATGGGCCGGCGTACTTCAAGCGTTATGACGAGCAATTTGCCAAATACACCCCTGTGTGCGAAGGTAATGAACTTGCCAAGTGT
GAACACCAATCGCTCATCAACGCCTATGATAATGCACTGCTTGCGACCGATGATTTTATCGCCAAAAGTATCGATTGGCTAAAAACGCAT
CAGGCCAACTATGATGTTGCCATGCTCTATGTCAGCGACCACGGCGAGAGTCTGGGTGAAAATGGCGTCTATCTGCATGGTATGCCAAAT
GCCTTTGCACCAAAAGAACAGCGAGCGGTACCGGCATTCTTTTGGTCAAATAATCCATCGTTCACGCCAACTGCCAGCGACACTGTGCTG
ACACATGATGCGATTACGCCGACTCTACTGAAGCTGTTTGATGTCACAGCGGATAAGGTCAAAGACCGCACCGCATTCATCCGCTGA