| Accession | ARO:3007070 |
| CARD Short Name | MCR-1.33 |
| Definition | An MCR-1-type colistin resistance gene variant, first described in a multi-drug-resistant Escherichia coli isolate recovered from a urinary tract infection, and co-occurring with the carbapenemase NDM-5. |
| AMR Gene Family | MCR phosphoethanolamine transferase |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Escherichia colip |
| Resistomes with Sequence Variants | Escherichia colip |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + mechanism of antibiotic resistance + lipopeptide antibiotic + antibiotic target alteration [Resistance Mechanism] + polymyxin antibiotic + determinant of antibiotic resistance + charge alteration conferring antibiotic resistance + gene altering cell wall charge + colistin + phosphoethanolamine transferase conferring colistin resistance + colistin B [Antibiotic] + colistin A [Antibiotic] |
| Parent Term(s) | 4 ontology terms | Show + evolutionary_variant_of MCR-1.1 + MCR phosphoethanolamine transferase [AMR Gene Family] + confers_resistance_to_antibiotic colistin A [Antibiotic] + confers_resistance_to_antibiotic colistin B [Antibiotic] |
| Publications | Bao D, et al. 2022. Infect Drug Resist 15:1499-1503 Emergence of a Multidrug-Resistant Escherichia coli Co-Carrying a New mcr-1.33 Variant and bla NDM-5 Genes Recovered from a Urinary Tract Infection. (PMID 35411158) |
Prevalence of MCR-1.33 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Escherichia coli | 0% | 0.01% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 1000