MCR-8.1

Accession ARO:3004516
DefinitionA novel phosphoethanolamine transferase and mobile colistin resistance gene identified from carbapenem-resistant NDM-1-producing Klebsiella pneumoniae.
AMR Gene FamilyMCR phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification15 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Publications

Wang X, et al. 2018. Emerg Microbes Infect 7(1):122 Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae. (PMID 29970891)

Resistomes

Prevalence of MCR-8.1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1000


>gb|AVX52225.1|-|MCR-8 [Klebsiella pneumoniae]
MFKYLLSFKLNPVQRTWAAAFFFTTIGNIALWQTLWINVDVHNIHNLLFFASLPIFLFCFLSILLTPVMVIPYLCRPLLVVLILISACCS
YFMMKYNILIDRSMVQNFFETNQAELTSYLSVPFLSTLFLLGIVPAIILALPSTDNKRGAFRIELWWLAHICIAVVLLAMVTMVFYKDYA
SLIRNNMQIKDQALPFNFVRNTNGYLKRKYQASSTILQSVGEDAVRPIYSNAPPKLVVVVVGETARAQNFQLNGYSRVTNPYLSRRHDVI
SFKNVSSCGTATAISLPCMFSRMSRNEYNEVRAASEENLLDILKRTGVEVLWRNNNNGGCKGICKRVPTDDMPAMKVIGECVNKDGTCFD
EVLLNQLSSRINAMQGDALIVLHQMGSHGPTYFERYPSTSKVFSPTCDSNLIEKCSNKELVNTYDNTLVYTDRMLSKTIELLQRYSGMRD
VAMIYLSDHGESLGESGIYLHGTPYIIAPNEQTHIPMFMWFSSSFAQHSKLNLECLTGNADKQYSHDNFYHSILGLFNVKTSVYKPELDM
FTLCRQSDHTPLSSAVVREKTDGNG


>gb|MG736312.1|-|50455-52152|MCR-8 [Klebsiella pneumoniae]
ATGTTCAAGTATCTTTTATCTTTCAAACTGAACCCGGTACAACGGACCTGGGCTGCAGCATTTTTTTTCACTACAATCGGCAACATAGCA
CTTTGGCAAACACTATGGATTAATGTAGATGTTCATAATATACATAATCTACTTTTTTTTGCCAGTCTGCCAATATTTCTTTTCTGCTTT
CTAAGTATCTTACTTACACCAGTCATGGTTATTCCATATTTATGCAGGCCTCTACTTGTAGTTCTTATTCTAATCAGTGCCTGCTGTAGT
TATTTCATGATGAAATACAACATATTAATTGACCGCAGCATGGTGCAAAACTTTTTTGAGACTAATCAGGCTGAATTAACATCATACTTA
TCCGTTCCTTTTCTTTCCACTCTATTTCTACTTGGCATTGTACCAGCAATTATCCTGGCGTTGCCTTCAACAGACAATAAGCGGGGAGCT
TTTAGAATTGAATTGTGGTGGTTGGCGCATATTTGCATAGCTGTAGTCTTATTAGCCATGGTTACCATGGTGTTTTATAAGGATTACGCA
TCTCTCATACGAAACAATATGCAGATTAAAGACCAGGCTTTACCTTTTAACTTTGTGCGTAATACGAATGGTTACCTTAAAAGAAAATAC
CAGGCATCTTCAACAATTCTACAAAGCGTGGGGGAGGATGCTGTACGTCCAATATATTCAAATGCTCCACCGAAACTGGTGGTTGTCGTC
GTGGGCGAAACCGCCAGAGCACAGAATTTCCAGCTGAATGGCTATTCGCGGGTAACCAACCCCTATCTTTCCAGACGACATGATGTTATC
AGTTTCAAAAATGTGTCGTCATGCGGAACGGCTACCGCAATATCACTACCCTGCATGTTCTCGCGAATGTCACGTAACGAATACAATGAA
GTCCGTGCCGCATCAGAAGAAAACTTGCTGGATATCCTTAAACGTACAGGTGTTGAGGTGCTATGGCGCAACAATAACAATGGTGGTTGT
AAGGGAATCTGCAAGCGAGTACCCACAGATGATATGCCGGCAATGAAAGTAATTGGGGAATGTGTTAACAAAGATGGTACATGCTTTGAT
GAGGTGTTATTAAATCAACTCTCATCCCGAATTAATGCAATGCAGGGTGATGCGCTTATTGTTTTACATCAAATGGGCAGTCATGGACCA
ACATATTTTGAACGTTATCCGTCTACAAGTAAAGTCTTTAGCCCAACTTGCGACAGCAACCTGATCGAAAAATGCTCAAATAAAGAACTG
GTCAATACATACGACAATACGCTAGTTTATACTGATCGTATGCTGAGCAAAACTATTGAACTGTTGCAACGTTATTCCGGGATGCGTGAC
GTTGCTATGATATATCTTTCTGATCATGGAGAATCGCTGGGGGAAAGCGGAATATATCTTCATGGCACACCATATATTATTGCCCCCAAT
GAACAAACACACATCCCGATGTTTATGTGGTTTTCGTCTTCATTCGCGCAGCATTCCAAATTAAATCTAGAATGCCTGACCGGTAATGCC
GACAAACAATACAGTCATGATAATTTTTATCATTCAATACTTGGTCTCTTCAACGTAAAAACCAGTGTATATAAACCGGAGTTAGATATG
TTTACTCTATGTCGACAATCTGACCACACACCACTGTCTTCCGCAGTTGTAAGAGAGAAAACAGATGGGAATGGTTAG