MCR-3.9

Accession ARO:3004508
CARD Short NameMCR-3.9
DefinitionAn MCR-3 polymyxin (incl. colistin) resistance gene variant isolated from an Aeromonas isolate.
AMR Gene FamilyMCR phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesAeromonas hydrophilag
Resistomes with Sequence VariantsAeromonas hydrophilag
Classification14 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ evolutionary_variant_of MCR-3.1
+ MCR phosphoethanolamine transferase [AMR Gene Family]
Publications

Eichhorn I, et al. 2018. J. Antimicrob. Chemother. 73(5):1217-1221 Identification of novel variants of the colistin resistance gene mcr-3 in Aeromonas spp. from the national resistance monitoring programme GERM-Vet and from diagnostic submissions. (PMID 29394397)

Resistomes

Prevalence of MCR-3.9 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Aeromonas hydrophila1.54%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1000


>gb|AST36144.1|+|MCR-3.9 [Aeromonas hydrophila]
MPSLIKIKIVPLIFFLALYFAFMLNWRGVLHFYEILYKLEDFKFGFAISLPILLVAALNFVFVPFSIRYLVKPFFALLIALSAIVSYTMM
KYRVLFDQNMIQNIFETNQNEALAYLSLPIIGWVTIAGFIPAILLFFVEIEYEKKWFKGIITRALSMFASLIVIAVIAALYYQDYVSVGR
NNSNLQREIVPANFVNSTVKYVYNRYLAEPIPFTTLGDDAKRDTNQSKPTLMFLVVGETARGKNFSMNGYEKDTNPFTSKSGGVISFNDV
RSCGTATAVSVPCMFSNMGRKEFDDNLARNSEGLLDVLQKTGVSIFWKENDGGCKGVCDRVPNIEIKPKDYPKFCDKNTCYDEVVLQELD
SEIAQMKGDKLVGFHLIGSHGPTYYKRYPDAHRQFTPDCPRSDIENCTDEELTNTYDNTIRYTDFVIGEMIAKLKTYEDKYNTALLYVSD
HGESLGALGLYLHGTPYKFAPDDQTRVPMQVWMSPGFTKEKGVDMACLQQKAADTRYSHDNIFSSVLGIWDVKTSVYEKGLDIFSQCRNV
Q


>gb|MF598080.1|+|1-1626|MCR-3.9 [Aeromonas hydrophila]
ATGCCTTCCCTTATAAAAATAAAAATTGTTCCGCTTATATTTTTTTTGGCACTGTATTTTGCATTTATGCTGAACTGGCGTGGAGTTCTC
CATTTTTACGAAATCCTTTACAAATTAGAAGATTTTAAGTTTGGTTTCGCCATTTCATTACCAATATTGCTTGTTGCAGCGCTTAACTTT
GTATTTGTTCCATTTTCGATACGGTATTTAGTAAAGCCTTTTTTTGCACTTCTGATCGCACTTAGTGCAATCGTTAGTTACACAATGATG
AAGTATAGAGTCTTGTTTGATCAAAACATGATTCAGAATATTTTTGAAACCAATCAAAATGAGGCCTTAGCATATTTAAGCTTACCAATT
ATAGGATGGGTTACTATTGCTGGCTTTATCCCTGCCATTTTACTTTTCTTTGTTGAAATTGAATATGAGAAAAAATGGTTCAAAGGGATT
ATAACTCGTGCCCTATCGATGTTTGCATCACTTATAGTGATTGCGGTTATTGCAGCACTATACTATCAAGATTATGTGTCAGTGGGGCGC
AACAATTCAAACCTCCAGCGTGAGATTGTTCCAGCCAATTTCGTTAATAGTACCGTTAAATACGTTTACAATCGTTATCTTGCTGAACCA
ATCCCATTTACAACTTTAGGTGATGATGCAAAACGGGATACTAATCAAAGTAAGCCCACGTTGATGTTTCTGGTCGTTGGTGAAACCGCT
CGTGGTAAAAATTTCTCGATGAATGGCTATGAGAAAGATACCAACCCATTCACAAGTAAGTCTGGTGGTGTGATCTCCTTTAATGATGTT
CGTTCGTGTGGGACTGCAACCGCTGTATCTGTCCCCTGCATGTTTTCCAATATGGGGAGAAAGGAGTTTGATGATAATCTCGCTCGTAAT
AGCGAGGGTTTGTTAGATGTGTTGCAGAAAACGGGGGTCTCCATTTTTTGGAAGGAGAACGATGGCGGCTGCAAAGGCGTCTGCGACCGA
GTTCCTAACATCGAGATCAAACCGAAGGATTACCCAAAGTTCTGCGATAAAAACACATGCTATGACGAGGTTGTCCTTCAAGAGCTCGAC
AGTGAAATTGCTCAAATGAAAGGGGATAAGCTGGTTGGCTTCCACCTGATAGGTAGCCATGGCCCAACCTACTACAAGCGCTACCCTGAT
GCTCATCGTCAGTTCACCCCTGACTGTCCACGCAGTGATATTGAAAACTGCACAGATGAAGAGCTCACCAACACCTATGACAACACCATC
CGCTACACCGATTTCGTGATTGGAGAGATGATTGCCAAGTTGAAAACCTACGAAGATAAGTACAACACCGCGTTGCTCTACGTCTCCGAT
CATGGTGAATCACTGGGAGCATTAGGGCTTTACCTACACGGTACACCGTACAAGTTTGCACCGGATGATCAGACCCGTGTTCCTATGCAG
GTGTGGATGTCACCTGGATTTACCAAAGAGAAAGGCGTTGATATGGCGTGTTTGCAGCAGAAAGCCGCTGATACTCGTTACTCACACGAT
AATATTTTCTCATCTGTATTGGGTATCTGGGACGTCAAAACATCAGTTTACGAAAAGGGTCTAGATATTTTCAGTCAATGTCGTAATGTT
CAATAA