Klebsiella mutant PhoP conferring antibiotic resistance to colistin

Accession ARO:3003585
CARD Short NameKleb_PhoP_CST
DefinitionA mutant phoP activates pmrHFIJKLM expression responsible for L-aminoarabinose synthesis and polymyxin resistance, by way of alteration of negative charge.
AMR Gene Familypmr phosphoethanolamine transferase, transmembrane protein conferring colistin resistance, ATP-binding cassette (ABC) antibiotic efflux pump
Drug Classpeptide antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target alteration, antibiotic efflux, resistance by absence
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Sequence VariantsKlebsiella pneumoniaewgs
Classification35 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ gene altering cell wall charge
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ phoP
+ confers_resistance_to_antibiotic colistin A [Antibiotic]

Jayol A, et al. 2015. Antimicrob Agents Chemother 59(5): 2780-2784. Heteroresistance to Colistin in Klebsiella pneumoniae Associated with Alterations in the PhoPQ Regulatory System. (PMID 25733503)


Prevalence of Klebsiella mutant PhoP conferring antibiotic resistance to colistin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Klebsiella pneumoniae0%0%0.01%0%
Show Perfect Only

Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 400


  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:

>gb|CDO13981.1|-|Klebsiella mutant PhoP conferring antibiotic resistance to colistin [Klebsiella pneumoniae]

>gb|FO834906.1|-|2325637-2326308|Klebsiella mutant PhoP conferring antibiotic resistance to colistin [Klebsiella pneumoniae]