pmr phosphoethanolamine transferase [AMR Gene Family]

Accession ARO:3004269
DefinitionThis family of phosphoethanolamine transferase catalyze the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine to lipid A, which impedes the binding of colistin to the cell membrane.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
7 ontology terms | Show
+ eptA
+ ugd
+ PmrF
+ arnA
+ eptB
+ ArnT
+ cprRS

Lee H, et al. 2004. J Bacteriol 186(13): 4124-4133. The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica. (PMID 15205413)

Gunn JS, et al. 1998. Mol Microbiol 27(6): 1171-1182. PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. (PMID 9570402)