Accession ARO:3005065
DefinitioncprRS is a two-component regulatory system. In the presence of cationic peptides, it induces the Arn operon to confer resistance.
AMR Gene Familypmr phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification17 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ pmr phosphoethanolamine transferase [AMR Gene Family]
+ regulates ArnT
+ regulates PmrF
+ regulates arnA
2 ontology terms | Show
+ cprR part_of
+ cprS part_of

Fernández L, et al. 2012. Antimicrob. Agents Chemother. 56(12):6212-22 The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS. (PMID 23006746)

Stover CK, et al. 2000. Nature 406(6799): 959-964. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. (PMID 10984043)

Winsor GL, et al. 2004. Nucleic Acids Res 33(DATABASE ISSUE): D338-D343. Pseudomonas aeruginosa Genome Database and PseudoCAP: facilitating community-based, continually updated, genome annotation. (PMID 15608211)

Winsor GL, et al. 2008. Nucleic Acids Res 37(DATABASE ISSUE): D483-D488. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. (PMID 18978025)