cprS

Accession ARO:3005064
CARD Short NamecprS
DefinitioncprS is part of a two-component regulatory system that, with its counterpart cprR, induces the Arn operon in the presence of cationic peptides to confer resistance.
AMR Gene Familypmr phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration, antibiotic efflux
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesPseudomonas aeruginosag+wgs, Pseudomonas fluorescensg
Resistomes with Sequence VariantsPseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg
Classification22 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Fernández L, et al. 2012. Antimicrob. Agents Chemother. 56(12):6212-22 The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS. (PMID 23006746)

Resistomes

Prevalence of cprS among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Pseudomonas aeruginosa98.93%0.58%67.74%0%
Pseudomonas fluorescens2.78%0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 800


>gb|AAG06466.1|+|cprS [Pseudomonas aeruginosa PAO1]
MKRGLSLIPIVGGGVTLILAGVLLVYTRMLGDYGETGALYLLSMMMEEEGLYFAQRYQEDPATPAPDSYYFKGSVGTAGLPPKLREMLDT
PPYKSIGAMQLLGNWDDDDEEEDDDAPSDDAYVVVRQPLADGKTLYLYDNDAAGSIDTPLSDAIIDARVRQTWIVTLSVTLPSLAAVGLL
VWFIVAPLRKLTRWSMTLDDLAPDSQRPRFNYRELNVLADTLWNSVTRIKDFSQREERFLRYASHELRTPLAVIGMNLELLDQPGRAPSP
HALQRIRRSALGMQQMTETLLWLSRESGELRDDGHIEVGRLLEELLEEQQALSQRRGLTFHLDVEPHSLPQTRARIIIGNLLRNALQYSD
EGVVEIVVRDRSLLISNPIGAAQGTEESMAFGYGLGLDLVQRLCQKSGWRLHYSSDEQRFRCELLFPATPD


>gb|AE004091.2|+|3451506-3452801|cprS [Pseudomonas aeruginosa PAO1]
ATGAAACGCGGCCTGAGCCTGATCCCCATCGTCGGCGGCGGCGTCACCCTGATCCTCGCCGGGGTGTTGCTGGTCTACACGCGCATGCTC
GGCGACTACGGCGAGACCGGCGCCCTCTACCTGCTCAGCATGATGATGGAAGAGGAAGGGCTGTACTTCGCCCAGCGCTACCAGGAAGAC
CCGGCTACGCCGGCGCCGGACAGCTACTACTTCAAGGGCAGCGTCGGCACCGCGGGGCTGCCGCCGAAACTCAGGGAGATGCTCGACACC
CCGCCCTACAAGAGCATCGGCGCCATGCAACTGCTCGGCAACTGGGACGACGATGACGAAGAGGAGGATGACGACGCGCCCAGCGACGAT
GCCTACGTGGTGGTCCGCCAGCCACTGGCCGACGGCAAGACGCTCTACCTCTACGACAACGACGCCGCCGGCAGCATCGACACGCCGCTG
TCCGACGCCATCATCGACGCCCGCGTCAGGCAGACCTGGATCGTCACCCTGTCGGTCACCCTGCCTTCGCTGGCCGCCGTCGGCCTGCTG
GTCTGGTTCATCGTCGCGCCGTTGCGCAAGCTGACGCGCTGGTCGATGACCCTCGACGACCTCGCCCCGGACAGCCAGCGGCCGCGCTTC
AACTACCGCGAACTCAACGTGCTGGCGGATACCCTGTGGAACAGCGTGACCCGGATCAAGGACTTCAGCCAGCGCGAGGAGCGCTTCCTG
CGCTACGCCAGCCATGAGCTGCGCACCCCGCTGGCGGTGATCGGCATGAACCTGGAGTTGCTCGACCAACCCGGCCGCGCGCCCTCCCCG
CATGCCTTGCAACGCATCCGCCGCTCGGCGCTGGGCATGCAGCAGATGACCGAGACCCTGCTCTGGCTCAGCCGCGAGAGCGGCGAACTG
CGCGACGACGGACACATCGAGGTCGGCCGCCTGCTGGAGGAACTGCTCGAGGAACAGCAGGCGCTGAGCCAGCGCCGCGGCCTGACCTTC
CACCTCGACGTGGAGCCACACAGCCTGCCGCAGACCCGCGCACGGATCATCATCGGCAACCTGCTGCGCAACGCCCTGCAGTACAGCGAC
GAGGGCGTGGTGGAAATCGTCGTGCGCGACCGCAGCCTGCTGATCAGCAACCCCATCGGTGCGGCCCAGGGCACGGAGGAGTCGATGGCG
TTCGGTTATGGCCTGGGCCTCGACCTGGTCCAGCGCCTGTGCCAGAAGAGTGGCTGGCGCCTGCATTACAGCAGCGACGAGCAGCGCTTC
CGCTGCGAGCTGCTGTTCCCCGCCACGCCGGACTGA