polymyxin B [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000454
DefinitionPolymyxin B is mixture of mostly polymyxins B1 and B2, mainly used for resistant gram-negative infections. They are polypeptides with cationic detergent action on cell membranes.
SMILESCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O
PubChem49800004
ChEMBLCHEMBL5314354
ChEMBLCHEMBL3989738
ChEBI59063
CAS1404-26-8
ChEBI8309
Drug Classpeptide antibiotic
Classification4 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
13 ontology terms | Show
+ polymyxin B1 [Antibiotic]
+ polymyxin B2 [Antibiotic]
+ polymyxin B3 [Antibiotic]
+ polymyxin B4 [Antibiotic]
+ LpsA confers_resistance_to_antibiotic
+ OmpA confers_resistance_to_antibiotic
+ PmrF confers_resistance_to_antibiotic
+ arnA confers_resistance_to_antibiotic
+ eptA confers_resistance_to_antibiotic
+ eptB confers_resistance_to_antibiotic
+ ugd confers_resistance_to_antibiotic
+ pgpB confers_resistance_to_antibiotic
+ LptD confers_resistance_to_antibiotic
Publications

Cardoso LS, et al. 2007. Microb Cell Fact 6: 1. Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. (PMID 17201926)
Curator Acknowledgements
Curator Description Most Recent Edit