| Accession | ARO:3005044 |
| CARD Short Name | OmpA |
| Definition | OmpA is a porin that confers resistance to beta-lactam antibiotics. |
| AMR Gene Family | General Bacterial Porin with reduced permeability to peptide antibiotics |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | reduced permeability to antibiotic |
| Resistomes with Perfect Matches | Klebsiella pneumoniaeg+wgs |
| Resistomes with Sequence Variants | Klebsiella aerogenesg, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Raoultella planticolag+wgs, Staphylococcus aureuswgs |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + peptide antibiotic [Drug Class] + determinant of antibiotic resistance + protein modulating permeability to antibiotic + lipopeptide antibiotic + General Bacterial Porin (GBP) + antibiotic mixture + polymyxin antibiotic |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic polymyxin B [Antibiotic] + confers_resistance_to_antibiotic defensin [Antibiotic] + General Bacterial Porin with reduced permeability to peptide antibiotics [AMR Gene Family] |
| Publications | Bialek-Davenet S, et al. 2014. Emerging Infect. Dis. 20(11):1812-20 Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. (PMID 25341126) |
Prevalence of OmpA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Klebsiella aerogenes | 2% | 0% | 0% | 0% |
| Klebsiella michiganensis | 100% | 0% | 63.83% | 0% |
| Klebsiella oxytoca | 97.44% | 0% | 72.69% | 0% |
| Klebsiella pneumoniae | 99.41% | 0.01% | 57.28% | 0% |
| Klebsiella quasipneumoniae | 100% | 0% | 73.16% | 0% |
| Raoultella planticola | 100% | 0% | 94.87% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.01% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700