| Accession | ARO:3004277 |
| Definition | General bacterial porins are a family of porins found in the outer membrane of Gram-negative bacteria. They catalyze the energy-independent transport of small molecules across the outer membranes of bacteria. Most of the porins of these family are homotrimeric and have variable selectivity, ranging from being cation-selective, anion-selective or selective for different compounds. The most well characterized members of this family are the OmpF and OmpC porins of Escherichia coli. This family is also known as the classical porins. |
| Resistance Mechanism | reduced permeability to antibiotic |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 2 ontology terms | Show + General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] + General Bacterial Porin with reduced permeability to peptide antibiotics [AMR Gene Family] |
| Publications | Pagès JM, et al. 2008. Nat. Rev. Microbiol. 6(12):893-903 The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. (PMID 18997824) |