polymyxin B1 [Antibiotic]

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Accession ARO:3000625
DefinitionPolymyxin B1 is in the family of polymyxin lipopeptides with a 6-methyloctanoic acid acyl group. These antibiotics disrupt the cell membrane of Gram-negative bacteria.
Drug Classpeptide antibiotic
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
4 ontology terms | Show
+ cell membrane component targeted by antibiotic targeted_by_antibiotic
+ RosAB confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ lipid A phosphatase [AMR Gene Family] confers_resistance_to_antibiotic

Orwa JA, et al. 2001. J Chromatogr A 912(2): 369-373. Isolation and structural characterization of polymyxin B components. (PMID 11330807)