cell membrane component targeted by antibiotic

Accession ARO:3000710
DefinitionInteraction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive.
Classification1 ontology terms | Show
Parent Term(s)15 ontology terms | Show
+ antibiotic target
+ targeted_by_antibiotic defensin [Antibiotic]
+ targeted_by polymyxin antibiotic
+ targeted_by_antibiotic gramicidin A [Antibiotic]
+ targeted_by_antibiotic gramicidin B [Antibiotic]
+ targeted_by_antibiotic gramicidin C [Antibiotic]
+ targeted_by_antibiotic gramicidin S [Antibiotic]
+ targeted_by_antibiotic magainin
+ targeted_by_antibiotic colistin A [Antibiotic]
+ targeted_by_antibiotic colistin B [Antibiotic]
+ targeted_by_antibiotic polymyxin B1 [Antibiotic]
+ targeted_by_antibiotic polymyxin B2 [Antibiotic]
+ targeted_by_antibiotic polymyxin B3 [Antibiotic]
+ targeted_by_antibiotic polymyxin B4 [Antibiotic]
+ targeted_by_antibiotic gramicidin [Antibiotic]
1 ontology terms | Show
+ menaquinone [Antibiotic]

Kelkar DA and Chattopadhyay A. 2007. Biochim Biophys Acta 1768(9): 2011-2025. The gramicidin ion channel: a model membrane protein. (PMID 17572379)

Michalopoulos AS and Karatza DC. 2010. Expert Rev Anti Infect Ther 8(9): 1009-1017. Multidrug-resistant Gram-negative infections: the use of colistin. (PMID 20818945)

White SH, et al. 1995. Curr Opin Struct Biol 5(4): 521-527. Structure, function, and membrane integration of defensins. (PMID 8528769)

Pache W, et al. 1972. Biochim Biophys Acta 255(1): 358-364. Interaction of antibiotics with membranes: polymyxin B and gramicidin S. (PMID 4334683)