gramicidin S [Antibiotic]

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Accession ARO:3000200
DefinitionGramicidin S is a cyclical decapeptide with two pentapeptides (Val-Orn-Leu-D-Phe-Pro) joined head to tail. Like other gramicidins, Gramicidin S disrupts membrane permeability of cations while also destabilizing the membrane at higher concentrations.
Drug Classpeptide antibiotic
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ gramicidin [Antibiotic]
1 ontology terms | Show

Kondejewski LH, et al. 1996. Int J Pept Protein Res 47(6): 460-466. Gramicidin S is active against both gram-positive and gram-negative bacteria. (PMID 8836773)

Prenner EJ, et al. 1999. Biochim Biophys Acta 1462(1-2): 201-221. The interaction of the antimicrobial peptide gramicidin S with lipid bilayer model and biological membranes. (PMID 10590309)