lipid A phosphatase [AMR Gene Family]

Accession ARO:3004287
DefinitionThe antimicrobial activity of certain antibiotics, such as peptide antibiotics, is proposed to be initiated through binding to the lipid A moiety of lipopolysaccharides. Thus, covalent modification of Gram-negative bacterial lipid A by phosphatases is a mechanism to reduce the susceptibility of the bacteria to antibiotics.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification11 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
+ confers_resistance_to_antibiotic polymyxin B1 [Antibiotic]
+ confers_resistance_to_antibiotic polymyxin B2 [Antibiotic]
+ confers_resistance_to_antibiotic polymyxin B3 [Antibiotic]
+ confers_resistance_to_antibiotic polymyxin B4 [Antibiotic]
+ determinant of polymyxin resistance
+ gene altering cell wall charge
Sub-Term(s)
1 ontology terms | Show
+ pgpB