ArnT

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Accession ARO:3005053
CARD Short NameArnT
DefinitionArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics.
AMR Gene Familypmr phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesKlebsiella pneumoniaeg
Resistomes with Sequence VariantsAeromonas enteropelogeneswgs, Aeromonas hydrophilag+wgs, Aeromonas veroniig+wgs, Citrobacter amalonaticusg+wgs, Citrobacter freundiig+p+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Cronobacter turicensiswgs, Edwardsiella tardag+wgs, Enterobacter asburiaeg+wgs, Enterobacter cancerogenusg+wgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+wgs, Escherichia marmotaeg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leclercia adecarboxylatag+wgs, Morganella morganiig+wgs, Pectobacterium parmentierig+wgs, Photorhabdus asymbioticag+wgs, Proteus columbaeg+wgs, Proteus mirabilisg+wgs, Proteus pennerig+wgs, Proteus vulgarisg+wgs, Providencia alcalifaciensg+p+wgs, Providencia heimbachaeg+wgs, Providencia rettgerig+wgs, Providencia stuartiig+wgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas brassicacearumwgs, Pseudomonas chlororaphisg+wgs, Pseudomonas fluorescensg+wgs, Pseudomonas koreensisg+wgs, Pseudomonas putidag+wgs, Pseudomonas synxanthag+wgs, Pseudomonas syringaeg+wgs, Raoultella planticolag+wgs, Salmonella bongorig+wgs, Salmonella entericag+wgs, Serratia liquefaciensg+wgs, Serratia marcescensg+p+wgs, Serratia odoriferawgs, Serratia rubidaeag+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs, Yersinia canariaeg+wgs, Yersinia enterocoliticag+wgs, Yersinia kristenseniig+wgs, Yersinia pestisg+wgs, Yersinia pseudotuberculosisg+wgs
Classification12 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ pmr phosphoethanolamine transferase [AMR Gene Family]
Sub-Term(s)
1 ontology terms | Show
+ cprRS regulates
Publications

Bialek-Davenet S, et al. 2014. Emerging Infect. Dis. 20(11):1812-20 Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. (PMID 25341126)
Resistomes

Prevalence of ArnT among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Aeromonas enteropelogenes0%0%12.5%0%0%
Aeromonas hydrophila100%0%98.39%0%0%
Aeromonas salmonicida0%0%0%0%100%
Aeromonas veronii3.64%0%3.37%0%0%
Citrobacter amalonaticus100%0%100%0%0%
Citrobacter freundii99.18%0.31%99.42%0%0%
Citrobacter portucalensis100%0%100%0%0%
Citrobacter werkmanii100%0%100%0%0%
Citrobacter youngae100%0%100%0%0%
Cronobacter turicensis0%0%8.33%0%0%
Edwardsiella tarda100%0%93.33%0%0%
Enterobacter asburiae87.1%0%99.21%0%0%
Enterobacter cancerogenus100%0%100%0%0%
Enterobacter chengduensis100%0%100%0%0%
Enterobacter cloacae80.36%0.56%85.3%0%0%
Enterobacter hormaechei33.81%0%33.71%0%0%
Enterobacter kobei100%0%99.13%0%0%
Enterobacter roggenkampii95.35%0%97.84%0%0%
Escherichia albertii100%0%99.35%0%0%
Escherichia coli67.58%0.04%99.32%0%99.65%
Escherichia fergusonii100%0%97.83%0%0%
Escherichia marmotae100%0%97.92%0%0%
Klebsiella aerogenes100%0%100%0%0%
Klebsiella huaxiensis100%0%100%0%0%
Klebsiella michiganensis100%0%100%0%0%
Klebsiella oxytoca100%0%100%0%0%
Klebsiella pneumoniae99.64%0%99.52%0%0%
Klebsiella quasipneumoniae100%0%99.87%0%0%
Kosakonia arachidis100%0%100%0%0%
Leclercia adecarboxylata14.29%0%6.98%0%0%
Morganella morganii100%0%100%0%0%
Pectobacterium parmentieri100%0%94.12%0%0%
Photorhabdus asymbiotica100%0%100%0%0%
Proteus columbae100%0%100%0%0%
Proteus mirabilis100%0%99.34%0%0%
Proteus penneri100%0%100%0%0%
Proteus vulgaris100%0%100%0%0%
Providencia alcalifaciens100%4%103.45%0%0%
Providencia heimbachae100%0%100%0%0%
Providencia rettgeri100%0%100%0%0%
Providencia stuartii100%0%97.73%0%0%
Pseudomonas aeruginosa98.93%0.58%97.51%0%0%
Pseudomonas brassicacearum0%0%16%0%0%
Pseudomonas chlororaphis98.77%0%95.16%0%0%
Pseudomonas fluorescens80.56%0%66.96%0%0%
Pseudomonas koreensis75%0%69.57%0%0%
Pseudomonas putida4.23%0%3.74%0%0%
Pseudomonas synxantha100%0%100%0%0%
Pseudomonas syringae89.58%0%90.02%0%0%
Raoultella planticola100%0%100%0%0%
Salmonella bongori100%0%100%0%0%
Salmonella enterica95.71%0%99.75%0%0%
Serratia liquefaciens100%0%100%0%0%
Serratia marcescens100%0.65%98.43%0%0%
Serratia odorifera0%0%100%0%0%
Serratia rubidaea100%0%100%0%0%
Shigella boydii100%0%98.89%0%0%
Shigella dysenteriae100%0%100%0%0%
Shigella flexneri100%0%99.84%0%0%
Shigella sonnei100%0%97.66%0%0%
Yersinia canariae100%0%100%0%0%
Yersinia enterocolitica100%0%99.55%0%0%
Yersinia kristensenii100%0%100%0%0%
Yersinia pestis100%0%99.22%0%0%
Yersinia pseudotuberculosis100%0%100%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|CDO12042.1|+|ArnT [Klebsiella pneumoniae]
MKSIRYGVSLIALFALYYLLPLNFRLLWQPDETRYAEISREMLATGDWVVPHFLGLRYFEKPIAGYWINSIGQWLFGHNNFGVRFGSVFA
ITMTALLVAWLAWRIFRDKRVAILSLIIFLTAMLVYAIGTYAVLDPMITLWLALAMCSFWGAVQAHSRSGKILGYVLLGVACGMGVMTKG
FLALAVPVVGVLPWVIARKRWREVLTYGWLAVIVCTLVVLPWGLAIAQREPDFWRYFFWVEHIQRFAEKDAQHKAPFWYYIPFLIAGSLP
WLALLPGALKRGWLERDEARGALYLLGWVAMPFLFFSIAKGKLPTYILPCFAPLSILMARYALEAAKTGAKALRINGMINLGVGLLGLIA
VLVVSPWGFMHKPVWTKIELYKCLLAAIAFAVWALMGWLAMKDSGRRWSLAALCPLGLALLVGFAIPDRVIDSKQPQFLVDIVSESLQPS
RYVLTNNVGIAGGLAWELKRSDIIMFDKQGELKYGLDWPDAQGSFVSQAGFADWLAAHRQQGPVSLVLLMDKGESMLDLPLPKPDNAYEL
GRVVFLQYLPQ


>gb|FO834906.1|+|304978-306633|ArnT [Klebsiella pneumoniae]
ATGAAAAGCATTCGCTATGGCGTCTCTCTGATTGCGCTGTTTGCGCTGTATTATCTGCTGCCGCTCAATTTCCGTTTGCTCTGGCAACCC
GACGAAACCCGCTACGCGGAGATCAGCCGTGAAATGCTGGCCACCGGCGACTGGGTGGTACCGCATTTTCTCGGCCTGCGCTACTTCGAA
AAACCGATTGCCGGTTACTGGATCAACAGTATCGGTCAGTGGCTGTTTGGCCATAATAACTTCGGCGTACGCTTCGGGTCGGTCTTCGCC
ATCACCATGACCGCCCTGCTGGTGGCCTGGCTGGCGTGGCGGATCTTTCGTGATAAGCGGGTAGCTATCCTGTCGCTGATTATCTTCCTC
ACCGCGATGCTGGTGTATGCGATTGGCACCTATGCGGTGCTGGACCCGATGATCACCCTGTGGCTGGCGCTGGCGATGTGCAGCTTCTGG
GGCGCGGTGCAGGCGCACAGCCGCAGCGGCAAAATACTGGGCTACGTGCTGCTGGGCGTCGCCTGCGGGATGGGGGTGATGACCAAGGGC
TTCCTGGCGCTGGCGGTGCCGGTGGTGGGCGTTCTGCCGTGGGTGATCGCCCGTAAACGCTGGCGTGAAGTGCTGACCTACGGCTGGCTG
GCGGTAATCGTCTGTACGCTGGTGGTGCTGCCCTGGGGGCTGGCTATCGCTCAGCGCGAGCCGGACTTCTGGCGCTACTTCTTCTGGGTC
GAGCATATTCAGCGTTTTGCTGAAAAAGACGCCCAGCACAAAGCGCCGTTCTGGTACTACATCCCGTTCCTGATCGCCGGCAGTCTGCCG
TGGCTGGCCCTGCTGCCGGGGGCGCTAAAGCGCGGCTGGCTTGAGCGCGATGAGGCCCGCGGCGCGCTGTATCTGTTAGGTTGGGTGGCG
ATGCCGTTCCTGTTCTTCAGTATCGCCAAAGGCAAACTGCCGACCTATATTCTGCCGTGCTTTGCGCCGCTGTCGATCCTGATGGCCCGC
TACGCGCTGGAGGCCGCAAAGACCGGCGCGAAAGCGTTGCGCATCAACGGGATGATCAACCTGGGCGTTGGTTTGCTGGGGCTTATCGCC
GTGCTGGTGGTCTCGCCGTGGGGCTTCATGCATAAGCCGGTGTGGACCAAGATTGAGCTGTATAAATGTCTGCTGGCGGCGATCGCTTTT
GCCGTCTGGGCGCTGATGGGCTGGCTGGCGATGAAAGACTCTGGCCGCCGCTGGAGCCTCGCCGCGCTCTGTCCGCTCGGCCTGGCGCTG
CTGGTGGGCTTCGCCATCCCGGACCGGGTTATCGACAGCAAACAGCCGCAGTTCCTCGTGGATATCGTCAGCGAATCCCTGCAGCCCAGC
CGTTACGTCCTGACCAACAACGTTGGGATCGCCGGCGGCCTGGCCTGGGAGCTGAAGCGAAGCGATATTATTATGTTCGACAAACAGGGT
GAGCTGAAGTACGGTCTCGACTGGCCGGATGCTCAGGGAAGCTTTGTCAGCCAGGCCGGTTTTGCCGACTGGCTGGCCGCGCATCGTCAG
CAGGGGCCGGTCTCGCTGGTGCTGTTGATGGATAAAGGAGAGAGTATGCTCGACTTACCGTTACCGAAACCGGATAACGCCTACGAGCTG
GGCCGGGTCGTTTTCCTTCAGTACCTGCCGCAATGA

Curator Acknowledgements
Curator Description Most Recent Edit